HCST / DAP10 Protein Product Information

Synonym : HCST, DAP10, KAP10, PIK3AP
Protein Construction: A DNA sequence encoding the human HCST (Q9UBK5-1) (Met-Pro48) was fused with Fc region of mouse IgG at the C-terminus.
Source: Human
Expression Host: Human Cell

HCST / DAP10 Protein QC Testing

Purity: (67.3+28) % as determined by SDS-PAGE SDS-PAGE
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Gln 19
Molecular Mass: The recombinant human HCST/mFc is a disulfide-linked homodimer. The reduced monomer comprises 264 amino acids and has a predicted molecular mass of 29.3 kDa. The apparent molecular mass of the protein is approximately 34 in SDS-PAGE under reducing conditions.
Formulation: Lyophilized from sterile PBS, pH 7.4.
                  1.Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
                  2.Please contact us for any concerns or special requirements.

HCST / DAP10 Protein Usage Guide

Storage:  Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:  A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

HCST / DAP10 Protein Description

HCST, also known as DAP10, belongs to the DAP10 family. It is a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. HCST may be part of the immune recognition receptor complex. This receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs). It may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif.

References

Wu J. et al., 1999, Science. 285 (5428): 730-2.
Karimi M. et al., 2006, J Immunol. 175 (12): 7819-28.
André P. et al., 2004, Eur J Immunol. 34 (4): 961-71.

規(guī)格：20ug

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