TGFβ1 / TGFB1 Protein Product Information

Synonym : TGFB1
Protein Construction: 
A DNA sequence encoding the rat TGFB1 (P17246) (Met1-Ser390) was expressed with a polyhistidine tag at the C-terminus.
Source: Rat
Expression Host: Human Cells

TGFβ1 / TGFB1 Protein QC Testing

Purity: > 90 % as determined by SDS-PAGE SDS-PAGE
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Leu 30
Molecular Mass: 
The recombinant rat TGFB1 comprises 372 amino acids and predicts a molecular mass of 42.7 kDa. The apparent molecular mass of  the recombinant protein is approximately 55, 38 and 16 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation: Lyophilized from sterile PBS, pH 7.4.
                 1.Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
                  2.Please contact us for any concerns or special requirements.

TGFβ1 / TGFB1 Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TGFβ1 / TGFB1 Protein Description

Transforming growth factor beta 1 (TGFβ1) is a member of the large transforming growth factor beta superfamily of cytokines, and serves as a multifunctional molecule performing actions in many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. TGFβ1 was first synthesized as a 390 amino acid precusor. The secreted proprotein contains 360 aa, and is cleaved into mature TGFβ1(112 aa) and latency-associated peptide (LAP)( 248 aa), which remains non-covalently linked to mature TGFβ1 rendering it inactive. TGFβ1 is synthesized by many cells, and regulates many other growth factors both in positive and negative manner. It has been shown that TGFβ1 plays an important role in controlling the immune system and shows different activities on different types of cell, or cells at different developmental stages. Highly expressed in bone and as a potent stimulator of osteoblastic bone formation, TGFβ1 is able to cause chemotaxis, proliferation and differentiation in committed osteoblasts. Further, TGFβ1 is also identified as a disease marker and a therapeutical target for cardiovascular disease. TGFβ activation from latency is controlled by multiple pathways including actions of some proteases, such as MMP9 and plasmin.

規(guī)格：10ug

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