CLEC5A / MDL1 / MDL-1蛋白產(chǎn)品信息

別名: CLEC5A
表達(dá)方式: 
A DNA sequence encoding the cynomolgus CLEC5A (XP_001085243.1) (Pro28-Arg188) was expressed with the Fc region of mouse IgG1 at the N-terminus.
種屬: Cynomolgus
表達(dá)宿主: Human Cells

CLEC5A / MDL1 / MDL-1 Protein QC Testing

純度: > 90 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測(cè)N端: Asp
分子量: 
The recombinant cynomolgus CLEC5A is a disulfide-linked homodimer. The reduced monomer comprises 397 amino acids and has a calculated molecular mass of 45.3 KDa. The apparent molecular mass of it is approximately 56 KDa respectively in SDS-PAGE.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CLEC5A / MDL1 / MDL-1 Protein Usage Guide

儲(chǔ)存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CLEC5A / MDL1 / MDL-1蛋白背景綜述

CLEC5A, also known as MDL1 and MDL-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. CLEC5A with dnax-activation protein 12 and may play a role in cell activation. It also functions as a positive regulator of osteoclastogenesis. CLEC5A acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation .The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.

參考文獻(xiàn)

Chen ST. et al., 2008, Nature. 453 (7195): 672-6.
Davila S. et al., 2010, Genes Immun. 11 (3): 232-8.
Hillier LW. et al., 2003, Nature. 424 (6945): 157-64.

規(guī)格：10ug

關(guān) 鍵 詞：Cynomolgus CLEC5A / MDL1 / MDL-1 Protein,使用說(shuō)明,廠家現(xiàn)貨，實(shí)驗(yàn)室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實(shí)驗(yàn)儀器，廠家

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