FGFR1蛋白產(chǎn)品信息

別名: FGFR1
表達方式: 
A DNA sequence encoding the cynomolgus FGFR1 (NP_075594.1) (Met1-Tyr283)  was expressed with a polyhistidine tag at the C-terminus.
種屬: Cynomolgus
表達宿主: Human Cells

FGFR1 Protein QC Testing

純度: > 95 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測N端: Arg 22
分子量: 
The recombinant cynomolgus FGFR1 comprises 273 amino acids and has a calculated molecular mass of 30.6 KDa. The apparent molecular mass of it is approximately 45-54 KDa  in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

FGFR1 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

FGFR1蛋白背景綜述

Fibroblast growth factor receptor 1 (FGFR1) is a member of the fibroblast growth factor receptor (FGFR) family, whose amino acid sequence is highly conserved between members throughout evolution. FGFR family members differ from one another in their ligand affinities , tissue distribution and have been implicated in a multitude of activities. FGFR1, also known as fms-related tyrosine kinase-2 (FLT2) and CD331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. This protein structurally consists of an extracellular region containing three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR1 is the receptor for FGF basic and also interacts with GRB14, SHB, FRS2. Defects in FGFR1 are the cause of several deseases, such as Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia (OGD), as well as Pfeiffer syndrome (PF).

參考文獻

Santos-Ocampo S. et al., 1996, J Biol Chem. 271 (3): 1726-31.
Stauber DJ. et al., 2000, Proc Natl Acad Sci. 97 (1): 49-54.
Pellegrini L. et al., 2000, Nature. 407 (6807): 1029-34.
Yu S. et al., 2002, Am J Physiol Endocrinol Metab. 283 (3): 490-5.
Hunter DJ. et al., 2007, Nature Genetics. 39: 870-4.

規(guī)格：50ug

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