ACVR2B / ACTRIIB蛋白產(chǎn)品信息

別名: ACVR2B
表達(dá)方式: 
A DNA sequence encoding the cynomolgus ACVR2B (EHH16502.1) (Ser28-Thr143) was expressed with the Fc region of human IgG1 at the C-terminus.
種屬: Cynomolgus
表達(dá)宿主: Human Cells

ACVR2B / ACTRIIB Protein QC Testing

純度: > 90 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測(cè)N端: Ser 28
分子量: 
The recombinant cynomolgus ACVR2B comprises 357 amino acids and has a calculated molecular mass of 40.3 KDa.The apparent molecular mass of the protein is approximately 54-62 KDa in SDS-PAGE.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

ACVR2B / ACTRIIB Protein Usage Guide

儲(chǔ)存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

ACVR2B / ACTRIIB蛋白背景綜述

Activin A receptor, type I IB, also known as ACTRIIB, or ACVR2B, is an activin type 2 receptor. Activins are dimeric growth and differentiation factors belonging to the TGF-beta superfamily. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I  (I and IB) and two type II (II and IIB) receptors. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. On ligand binding, Type I and II receptors form a stable complex, resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity, and subsequently the initiates activation of downstream molecules. The activin A type IIB receptor displays a 3- to 4-fold higher affinity for the ligand than the type II receptor. Mouse activin receptor IIB (ACVR2B) is a transmembrane proteins consisting of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane segment, a cytoplasmic domain with predicted serine/threonine specificity, and as well as a C-terminal PDZ binding motif . Mouse ACVR2B shares 99% aa sequence identity with human and rat within ECD.

參考文獻(xiàn)

Hilden K. et al., 1994, Blood. 83: 2163-70.
Persson U. et al., 1997, J Biol Chem. 272: 21187-94.
Manova K. et al., 1995, Mech Dev. 49: 3-11.
Matzuk MM. et al., 1992, Biochem Biophys Res Commun.185: 404-13.

規(guī)格：100ug

關(guān) 鍵 詞：Cynomolgus ACVR2B / ACTRIIB Protein,技術(shù)資料,價(jià)格，實(shí)驗(yàn)室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實(shí)驗(yàn)儀器，廠家

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