BAFFR / TNFRSF13C蛋白產(chǎn)品信息

別名: TNFRSF13C
表達(dá)方式: 
A DNA sequence encoding the rat TNFRSF13C (XP_576316.2) (Ser10-Ala71) was expressed with the Fc region of human IgG1 at the C-terminus.
種屬: Rat
表達(dá)宿主: Human Cells

BAFFR / TNFRSF13C Protein QC Testing

純度: > 90 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測(cè)N端: Ser 10
分子量: 
The recombinant rat TNFRSF13C/Fc is a disulfide-linked homodimer. The reduced monomer comprises 303 amino acids and has a predicted molecular mass of 33.8 kDa. The apparent molecular mass of the protein is approximately 42 kDa in SDS-PAGE under reducing conditions due to glycosylation.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

BAFFR / TNFRSF13C Protein Usage Guide

儲(chǔ)存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

BAFFR / TNFRSF13C蛋白背景綜述

Tumor necrosis factor receptor superfamily member 13C, also known as B-cell-activating factor receptor, BAFF receptor, BLyS receptor 3, CD268, TNFRSF13C and BAFFR, is a single-pass type III membrane protein which contains one TNFR-Cys repeat. TNFRSF13C / BAFFR is highly expressed in spleen and lymph node, and in resting B-cells. It is detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes. TNFRSF13C / BAFFR is a B-cell receptor specific for TNFSF13B / TALL1 / BAFF / BLyS. TNFRSF13C / BAFFR promotes the survival of mature B-cells and the B-cell response. Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) which is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins.

參考文獻(xiàn)

Thompson JS. et al., 2001, Science. 293 (5537): 2108-11.
Laabi Y. et al., 2002, Curr Biol. 11 (24): R1013-6.
Defrance T. et al.,2003, Adv Cancer Res. 86: 195-225.
Ambrose CM. et al., 2003, J Biol Regul Homeost.Agents. 16 (3): 211-3.

規(guī)格：50ug

關(guān) 鍵 詞：Rat BAFFR / TNFRSF13C Protein,鼠BAFFR / TNFRSF13C蛋白質(zhì),使用說(shuō)明,價(jià)格，實(shí)驗(yàn)室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實(shí)驗(yàn)儀器，廠家

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