CXCL16 / SRPSOX蛋白產(chǎn)品信息

別名: CXCL16
表達(dá)方式: 
A DNA sequence encoding the canine CXCL16 (XP_849304.2) (Met1-Ser205) was expressed with the Fc region of human IgG1 at the C-terminus.
種屬: Canine
表達(dá)宿主: Human Cells

CXCL16 / SRPSOX Protein QC Testing

純度: > 95 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測N端: Asn 22
分子量: 
The recombinant canine CXCL16/Fc is a disulfide-linked homodimer. The reduced monomer comprises 425 amino acids and has a predicted molecular mass of 47.1 kDa. The apparent molecular mass of the protein is approximately 56-67 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CXCL16 / SRPSOX Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CXCL16 / SRPSOX蛋白背景綜述

C-X-C motif chemokine 16, also known as Small-inducible cytokine B16, SR-PSOX, and CXCL16, is a single-pass type I membrane protein which belongs to the intercrine alpha (chemokine CxC) family. It is expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. It is weakly expressed in heart and liver and no expression in brain and bone marrow. CXCL16 is expressed on the surface of APCs including subsets of CD19(+) B cells and CD14(+) monocyte / macrophages, and functional CXCL16 is also shed from macrophages. CXCL16 is an alpha (CXC) chemokine but also has characteristics of CC chemokines and a structure similar to fractalkine (neurotactin) in having a transmembrane region and a chemokine domain suspended by a mucin-like stalk. CXCL16 may function in promoting interactions between DCs and CD8 T cells and in guiding T cell movements in the splenic red pulp. CXCL16 was also found in the thymic medulla and in some nonlymphoid tissues, indicating roles in thymocyte development and effector T cell trafficking.

參考文獻(xiàn)

Matloubian M. et al., 2000, Nat Immunol. 1 (4): 298-304.
Wilbanks A. et al., 2001, J Immunol. 166 (8): 5145-54.
Abel S. et al., 2004, J Immunol. 172 (10): 6362-72.

規(guī)格：20ug

關(guān) 鍵 詞：Canine CXCL16 / SRPSOX Protein,產(chǎn)品詳情,價格,廠家，實驗室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實驗儀器，廠家

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