EDEM2 / C20orf31蛋白產(chǎn)品信息

別名: EDEM2, C20orf31, C20orf49
表達方式: 
A DNA sequence encoding the human EDEM2 (AAH01371.1) (Met1-Lys492) was expressed with a polyhistidine tag at the C-terminus.
種屬: Human
表達宿主: Human Cells

EDEM2 / C20orf31 Protein QC Testing

純度: > 95 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Ala 22
分子量: 
The recombinant human EDEM2 consists of  482 amino acids and predicts a molecular mass of  54 KDa. It migrates as an approximately 53-58 KDa band in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

EDEM2 / C20orf31 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

EDEM2 / C20orf31蛋白背景綜述

EDEM2, also known as C20orf31, belongs to a family of proteins involved in ER-associated degradation (ERAD) of glycoproteins. In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome. Early in this pathway, a proposed lumenal ER lectin, EDEM, recognizes misfolded glycoproteins in the ER, disengages the nascent molecules from the folding pathway, and facilitates their targeting for disposal. In humans there are a total of three EDEM homologs. The amino acid sequences of these proteins are different from other lectins but are closely related to the Class I mannosidases (family 47 glycosidases). EDEM2 is one of the EDEM homologs. Overexpression of EDEM2 accelerates the degradation of misfolded alpha1-antitrypsin, indicating that the protein is involved in ERAD.

參考文獻

Mast SW. et al., 2005, Glycobiology. 15 (4): 421-36.
Olivari S. et al., 2005, J Biol Chem. 280 (4): 2424-8.
Ota T. et al., 2004, Nat Genet. 36 (1): 40-5.

規(guī)格：20ug

關(guān) 鍵 詞：EDEM2 / C20orf31 Protein,EDEM2 / C20orf31蛋白質(zhì),技術(shù)資料,現(xiàn)貨，實驗室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實驗儀器，廠家

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