SELE / selectin E / CD62E蛋白產(chǎn)品信息

別名: SELE
表達(dá)方式: 
A DNA sequence encoding the mouse SELE (NP_035475.1)(Met1-Pro564) was expressed with the Fc region of human IgG1 at the C-terminus.
種屬: Mouse
表達(dá)宿主: Human Cells

SELE / selectin E / CD62E Protein QC Testing

純度: > 90% as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測N端: Trp 29
分子量: 
The recombinant mouse SELE/Fc is a disulfide-linked homodimer. The reduced monomer comprises 777 amino acids and has a predicted molecular mass of 85.5 kDa. The apparent molecular mass of the protein is approximately 101 kDa in SDS-PAGE under reducing conditions due to glycosylation.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

SELE / selectin E / CD62E Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

SELE / selectin E / CD62E蛋白背景綜述

E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62E, is an inducible adhesion molecule that is expressed at relatively high density on the surface of cultured endothelial cells that have been activated by proinflammatory cytokines, such as IL-1β, TNF-α, or bacterial endotoxin. E-Selectin/CD62e exhibits a complex mosaic structure consisting of a large extracellular region comprised of a lectin domain, an EGF-like domain, and a short consensus repeat (SCR) domain, followed by a transmembrane region and a relatively short (32 aa) cytoplasmic tail. As a member of the LEC-CAM or selectin family, E-Selectin/CD62e recognises and binds to sialylated carbohydrates including members of the Lewis X and Lewis A families found on monocytes, granulocytes, and T-lymphocytes. E-Selectin/CD62e supports rolling and stable arrest of leukocytes on activated vascular endothelium, and furthermore, it was indicated that it can also transduce an activating stimulus via the MAPK cascade into the endothelial cell during leukocyte adhesion. In addition, this adhesion molecule appears to be involved in the pathogenesis of atherosclerosis.

參考文獻(xiàn)

Hession C. et al., 1990, Proc Natl Acad Sci. 87: 1673-7.
Philips ML. et al., 1990, Science. 250: 1130-2.
Luo J. et al., 1999, Blood. 93: 3785-91.
Hu Y. et al., 2001, J Biol Chem. 276: 48549-53.
Bevilacqua MP. et al., 1993, J Clin Invest. 91: 379-84.

規(guī)格：100ug

關(guān) 鍵 詞：Mouse SELE / selectin E / CD62E Protein，使用說明，現(xiàn)貨，實(shí)驗(yàn)室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實(shí)驗(yàn)儀器，廠家

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