OX-40L / TNFSF4蛋白產(chǎn)品信息

別名: TNFSF4
表達(dá)方式: 
A DNA sequence encoding the cynomolgus TNFSF4 (F7FL80) (Gln51-Leu183) was expressed with the Fc region of mouse IgG1 at the N-terminus.
種屬: Cynomolgus
表達(dá)宿主: Human Cells

OX-40L / TNFSF4 Protein QC Testing

純度: > 85 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測(cè)N端: Asp
分子量: 
The recombinant cynomolgus TNFSF4 is a disulfide-linked homodimer. The reduced monomer comprises 369 amino acids and has a calculated molecular mass of 42 KDa.The apparent molecular mass of it is approximately 48 KDa respectively in SDS-PAGE.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

OX-40L / TNFSF4 Protein Usage Guide

儲(chǔ)存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

OX-40L / TNFSF4蛋白背景綜述

OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. OX-40L is a ligand for receptor TNFRSF4/OX4. It is found to play a role in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.

參考文獻(xiàn)

Lei W. et al., 2012, Ann Acad Med Singapore. 41 (5): 200-4.
Lee YH. et al., 2012, Hum Immunol. 73 (10): 1050-4.
Weiguang Y. et al., 2012, PLoS One. 7 (8): e41277.

規(guī)格：20ug

關(guān) 鍵 詞：Cynomolgus OX-40L / TNFSF4 Protein,技術(shù)資料,現(xiàn)貨，實(shí)驗(yàn)室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實(shí)驗(yàn)儀器，廠家

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