IFNB1 / IFN-beta / Interferon beta蛋白產(chǎn)品信息
別名: IFNB1
表達(dá)方式:
A DNA sequence encoding the cynomolgus IFNB1(G7NFX1) (Met1-Asn187) was expressed with Fc region of mouse IgG at the C-terminus.
種屬: Cynomolgus
表達(dá)宿主: Human Cells
IFNB1 / IFN-beta / Interferon beta Protein QC Testing
純度: > 85 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測(cè)N端: Met 22
分子量:
The recombinant cynomolgus IFNB1 is a disulfide-linked homodimer. The reduced monomer comprises 400 amino acids and has a calculated molecular mass of 46.4 KDa.The apparent molecular mass of the protein is approximately 44-49 KDa respectively in SDS-PAGE.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
IFNB1 / IFN-beta / Interferon beta Protein Usage Guide
儲(chǔ)存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
IFNB1 / IFN-beta / Interferon beta蛋白背景綜述
Interferon beta 1(IFN beta1) or IFNB1 is one type of IFN beta proteins that is a member of the Interferon type I family. Interferon beta 1(IFN beta1) or IFNB1 is produced in large quantities by fibroblasts and binds to a specific cell surface receptor complex known as the IFN alpha receptor (IFNAR) that consists of IFNAR1 and IFNAR2 chains as other members of IFN1 famlily do. The induction of interferon beta (IFNB1) is a key event in the antiviral immune response. It has shown that treatment with IFN beta affects NK cell cycle without altering NK cell apoptosis in MS patients. Treated with IFN beta alone or in combination with low-dose prednisolone displayed increased proportion of all NK cell subsets in the active phase of the cell cycle. There was no difference in NK cell apoptosis markers. Synthetic interferons (IFNs) are used in the treatment of several types of cancer. It has also been proved that apoptosis was decreased by IFN treatment, whereas inhibition of proliferation is caused by cell cycle arrest in late S-phase.
參考文獻(xiàn)
Sanvito L. et al., 2011, J Neuroimmunol. 236 (1-2): 111-7.
Erdmann J. et al., 2011, J Interferon Cytokine Res. 31 (5): 451-8.
Biron CA. et al., 2002, Curr Top Microbiol Immunol. 263: 7-27.
規(guī)格:50ug
關(guān) 鍵 詞:Cynomolgus IFNB1 / IFN-beta / Interferon beta Protein,使用說(shuō)明,產(chǎn)品詳情,實(shí)驗(yàn)室耗材,生化試劑,上海創(chuàng)賽,博飛美科,實(shí)驗(yàn)儀器,廠家
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