NOV / CCN3蛋白產(chǎn)品信息

別名: NOV
表達(dá)方式: 
A DNA sequence encoding the canine NOV(XP_532317.3) (Met1-Met353) was expressed with a C-terminal polyhistidine tag.
種屬: Canine
表達(dá)宿主: Human Cells

NOV / CCN3 Protein QC Testing

純度: > 85 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測(cè)N端: Gln 29
分子量: 
The recombinant canine NOV comprises 336 amino acids and has a predicted molecular mass of 36.9 kDa. The apparent molecular mass of the protein is approximately 40-47 kDa in SDS-PAGE under reducing conditions due to glycosylation.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

NOV / CCN3 Protein Usage Guide

儲(chǔ)存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

NOV / CCN3蛋白背景綜述

Protein NOV homolog, also known as Nephroblastoma-overexpressed gene protein homolog, NOV, and CCN3, is secreted protein which belongs to the CCN family. CCN3 expression was observed in a broad variety of tissues from the early stage of development. It contains one CTCK (C-terminal cystine knot-like) domain, one IGFBP N-terminal domain, one TSP type-1 domain, and one VWFC domain. CCN3, a founding member of the CCN family of growth regulators, was linked with hematology in 2003 when it was detected in human serum. CCN3 acts through the core stem cell signalling pathways including Notch and Bone Morphogenic Protein, connecting CCN3 with the modulation of self-renewal and maturation of a number of cell lineages including hematopoietic, osteogenic and chondrogenic. Altered CCN3 expression is associated with numerous solid tumors including glioblastoma, melanoma, adrenocortical tumours, prostate cancer and bone malignancies including osteosarcoma. CCN3 may affect the extracellular environment of the niche for hematopoietic stem cells. CCN3 has emerged as a key player in stem cell regulation, hematopoiesis and a crucial component within the bone marrow microenvironment.

參考文獻(xiàn)

Lombet A. et al., 2003,Cell Commun Signal. 1 (1): 1.
Katsube K. et al., 2009, J Cell Commun Signal. 3 (2): 135-45.
McCallum L. et al., 2009,  Blood Rev. 23 (2): 79-85.
McCallum LJ. et al., 2009, Cell Commun Signal. 3 (2):115-24.

規(guī)格：50ug

關(guān) 鍵 詞：Canine NOV / CCN3 Protein ,價(jià)格,參數(shù)，實(shí)驗(yàn)室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實(shí)驗(yàn)儀器，廠家

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