ICAM4 / CD242蛋白產(chǎn)品信息

別名: ICAM4, LW
表達方式: 
A DNA sequence encoding the human ICAM4 (NP_001034221.1) (Met1-Gly272) was expressed with the Fc region of human IgG1 at the C-terminus.
種屬: Human
表達宿主: Human Cells

ICAM4 / CD242 Protein QC Testing

純度: (50.3+36.1) % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Ala 23
分子量: 
The recombinant human ICAM4/Fc is a disulfide-linked homodimer. The reduced monomer comprises 491 amino acids and has a predicted molecular mass of 54.4 kDa. The apparent molecular mass of the protein is approximately 55 and 33 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

ICAM4 / CD242 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

ICAM4 / CD242蛋白背景綜述

ICAM4, also known as CD242, is a member of the?immunoglobulin superfamily, ICAM family. ICAM4 contains 2?Ig-like C2-type (immunoglobulin-like) domains. It is similar to the intercellular adhesion molecule (ICAM) protein family. ICAM4 binds to the leukocyte adhesion LFA-1 protein. ICAM4's first reported receptors were CD11a/CD18 and CD11b/CD18. ICAM4 functions as a ligand for the monocyte/macrophage-specific CD11c/CD18. Deletion of the individual immunoglobulin domains of ICAM4 demonstrated that both its domains contain binding sites for CD11c/CD18. CD11c/CD18 is expressed on macrophages in spleen and bone marrow. Inhibition of erythrophagocytosis by anti-ICAM4 and anti-integrin antibodies suggests a role for these interactions in removal of senescent red cells.

參考文獻

Gorst DW. et al., 1980, Vox Sanguinis. 38 (2): 99-105.
Vos GH. et al., 1973, Blood. 42 (3): 445-53.
Kim W. et al., 2011, Mol Cell. 44 (2): 325-40.
Daniels G. et al., 2002, Transfusion Medicine. 12 (5): 287-95.

規(guī)格：50ug

關 鍵 詞：ICAM4 / CD242 Protein,廠家現(xiàn)貨,報價，實驗室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實驗儀器，廠家

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