CD4蛋白產(chǎn)品信息

別名: CD4
表達(dá)方式: 
A DNA sequence encoding the cynomolgus CD4 (G7N5T8) (Met1-Trp390) was expressed with a polyhistidine tag at the C-terminus.
種屬: Cynomolgus
表達(dá)宿主: Human Cells

CD4 Protein QC Testing

純度: > 95 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測N端: Lys 26
分子量: 
The recombinant cynomolgus CD4 comprises 376 amino acids and has a calculated molecular mass of 41.8 KDa. The apparent molecular mass of it is approximately 48-53 KDa  in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CD4 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD4蛋白背景綜述

T-cell surface glycoprotein CD4, also known as T-cell surface antigen T4/Leu-3, is a single-pass type I  membrane protein. CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CD4 is a glycoprotein expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells. It was discovered in the late 1970s and was originally known as leu-3 and T4 before being named CD4 in 1984. CD4 is a co-receptor that assists the T cell receptor (TCR) to activate its T cell following an interaction with an antigen presenting cell. Using its portion that resides inside the T cell, CD4 amplifies the signal generated by the TCR. CD4 interacts directly with MHC class II molecules on the surface of the antigen presenting cell via its extracellular domain. CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors. Therefore, medical professionals refer to the CD4 count to decide when to begin treatment for HIV-infected patients.

參考文獻(xiàn)

Ryu SE. et al., 1994, Structure 2 (1): 59-74.
Isobe M. et al., 1986, Proc. Natl. Acad. Sci. 83 (12): 4399-402.
Ansari-Lari MA. et al., 1996, Genome Res. 6 (4): 314-26.
Hawash. et al., 2002, Biochim Biophys Acta. 1589 (2): 140-50.

規(guī)格：50ug

關(guān) 鍵 詞：Cynomolgus CD4 Protein,技術(shù)資料,現(xiàn)貨，實驗室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實驗儀器，廠家

CANSPEC品質(zhì)提供的Cynomolgus CD4 Protein|技術(shù)資料|現(xiàn)貨性能**，其優(yōu)良的品質(zhì)滿足您不同實驗的多種需求。

本產(chǎn)品由上海創(chuàng)賽品質(zhì)提供，歡迎咨詢國內(nèi)免費(fèi)服務(wù)專線：400-608-7598，更多產(chǎn)品信息請登錄www.ahbcpqn.cn 或 www.4006087598.com