IL2RA蛋白產(chǎn)品信息

別名: IL2RA
表達(dá)方式: 
A DNA sequence encoding the cynomolgus IL2RA (H6WS54) (Met1-Arg213) was expressed with the Fc region of human IgG1 at the C-terminus.
種屬: Cynomolgus
表達(dá)宿主: Human Cells

IL2RA Protein QC Testing

純度: > 90 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測N端: Glu 22
分子量: 
The recombinant cynomolgus IL2RA is a disulfide-linked homodimer. The reduced monomer comprises 433 amino acids and has a calculated molecular mass of 48.7 KDa.The apparent molecular mass of the protein is approximately 65 KDa respectively in SDS-PAGE.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

IL2RA Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL2RA蛋白背景綜述

Interleukin 2 receptor alpha (IL2Rα), also known as CD25 molecule, is a type I transmembrane glycoprotein with a signal peptide, an extracellular region, a transmembrane region, and a cytoplasmic domain. IL2Rα / CD25 is expressed on activated T cells and regulatory T cells, and is capable of binding IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2Rα is associated non-covelently with the IL2 receptor beta and gamma chain, and subsequently initiates the intacellular signal pathways such as MAPK or JAK/STAT. Accordingly, IL2 receptor complex mediates the IL2 effects via regulating T cell proliferation, activation and other lymphoid functions, and IL2Rα has been shown to deliver IL2 to the signaling complex and act as a regulator of signal transduction. In addition, IL2 induces IL2R transcription via an IL2-responsive enhancer, and IL2R also inhibits IL2 gene expression by activating the expression of CTLA-4 or FOXP3 via the negative feedback loops.

參考文獻(xiàn)

Purvis SF. et al., 1992, Cell Immunol. 144: 32-42.
Rusterholz C. et al., 1999, Mol Cell Biol. 19: 2681-9.
Kim HP. et al., 2005, J Biol Chem. 280: 34042-7.
Stauber DJ. et al., 2006, Proc Natl Acad Sci. 103: 2788-93.
Fragale A. et al., 2008, J Immunol. 181: 1673-82.

規(guī)格：50ug

關(guān) 鍵 詞：Cynomolgus IL2RA Protein,技術(shù)資料,廠家現(xiàn)貨，實驗室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實驗儀器，廠家

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