TFRC / Transferrin Receptor蛋白產(chǎn)品信息

別名: TFRC, Tfrc
表達方式: 
A DNA sequence encoding the cynomolgus TFRC (NP_001244232.1) (Cys89-Phe760) was expressed with a polyhistidine tag at the N-terminus.
種屬: Cynomolgus
表達宿主: Human Cells

TFRC / Transferrin Receptor Protein QC Testing

純度: > 95 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測N端: His
分子量: 
The recombinant cynomolgus TFRC comprises 692 amino acids and has a calculated molecular mass of 77.6 KDa. The apparent molecular mass of it is approximately 65-85 KDa  in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

TFRC / Transferrin Receptor Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TFRC / Transferrin Receptor蛋白背景綜述

Transferrin receptor protein 1, also known as transferrin receptor, Trfr, p90, CD71 and TFRC, is a single-pass type II membrane protein which belongs to the peptidase M28 family and M28B subfamily. TFRC / CD71 is a membrane-bound protein expressed in larger amounts in proliferating. The specific expression of TFRC can represent a diagnostic tool or a therapeutic target in solid tumours expressing this antigen. Transferrin receptor is necessary for development of erythrocytes and the nervous system. TFRC / CD71 is regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation. TFRC / CD71 represents a marker of malignant transformation in  UIOP[] the pancreas that could be applied as potential diagnostic and therapeutic target.

參考文獻

Douabin-Gicquel V. et al., 2001, Hum Genet. 109: 393-401.
Ryschich E. et al., 2004, Eur J Cancer. 40 (9): 1418-22.
Tosoni D. et al., 2005, Cell. 123: 875-88.
Wollscheid B. et al., 2009, Nat Biotechnol. 27: 378-86.

規(guī)格：50ug

關(guān) 鍵 詞：Cynomolgus TFRC / Transferrin Receptor Protein,廠家現(xiàn)貨,價格，實驗室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實驗儀器，廠家

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