FLT3 / FLK2 / CD135蛋白產(chǎn)品信息

別名: FLT3
表達(dá)方式: 
A DNA sequence encoding the mouse FLT3 (EDL05833.1) (Met1-Ser544) was expressed with a C-terminal polyhistidine tag.
種屬: Mouse
表達(dá)宿主: Human Cells

FLT3 / FLK2 / CD135 Protein QC Testing

純度: > 95 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測(cè)N端: Asn 28
分子量: 
The recombinant mouse FLT3 comprises 528 amino acids and has a predicted molecular mass of 59.5 kDa. The apparent molecular mass of the protein is approximately 73 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

FLT3 / FLK2 / CD135 Protein Usage Guide

儲(chǔ)存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

FLT3 / FLK2 / CD135蛋白背景綜述

FL cytokine receptor, also known as tyrosine-protein kinase receptor FLT3, Stem cell tyrosine kinase 1, STK-1, FLT3 and CD135, is a single-pass type I  membrane protein. CD135 belongs to the protein kinase superfamily and the CSF-1/PDGF receptor subfamily. It contains one Ig-like C2-type domain and one protein kinase domain. CD135 is an important cell surface marker used to identify certain types of hematopoietic progenitors in the bone marrow. Specifically, multipotent progenitors (MPP) and common lymphoid progenitors (CLP) express surface CD135 at high levels. This marker is therefore used to differentiate hematopoietic stem cells (HSC), which are CD135 negative, from MPPs, which are CD135 positive. Signaling through CD135 plays a role in cell survival, proliferation, and differentiation. CD135 is also important for lymphocyte (B cell and T cell) development, but not for the development of other blood cells (myeloid development). Identified as a proto-oncogene, the mutations of FLTS gene are associated with certain carcinomas.

參考文獻(xiàn)

Reilly JT. et al., 2003, Leuk Lymphoma. 44 (1): 1-7.
Marcucci G. et al., 2005, Curr Opin Hematol. 12 (1): 68-75.
Sternberg DW. et al.,2005, Curr Opin Hematol. 12 (1): 7-13.
Stubbs MC. et al., 2007, Current drug targets. 8 (6): 703-14.

規(guī)格：20ug

關(guān) 鍵 詞：Mouse FLT3 / FLK2 / CD135 Protein,技術(shù)資料,廠家現(xiàn)貨，實(shí)驗(yàn)室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實(shí)驗(yàn)儀器，廠家

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