REG4 / RELP / GISP蛋白產(chǎn)品信息

別名: REG4, GISP, RELP
表達方式: 
A DNA sequence encoding the human REG4 (Q9BYZ8-1) (Asp23-Pro158) was expressed with the fused Fc region of human IgG1 at the N-terminus.
種屬: Human
表達宿主: Human Cells

REG4 / RELP / GISP Protein QC Testing

純度: > 90 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Glu
分子量: 
The recombinant human REG4/Fc is a disulfide-linked homodimer. The reduced monomer comprises 396 amino acids and has a predicted molecular mass of 44.3 kDa. The apparent molecular mass of the protein is approximately 45 kDa in SDS-PAGE under reducing conditions due to glycosylation.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

REG4 / RELP / GISP Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

REG4 / RELP / GISP蛋白背景綜述

Regenerating islet-derived protein 4, also known as REG-like protein, REG4, GISP and RELP, is a secreted protein which contains one C-type lectin domain. REG4 is involved in inflammatory and metaplastic responses of the gastrointestinal epithelium. REG4 is highly expressed in the gastrointestinal tract including the duodenum, jejunum, ileum, ileocecum, appendix, descending colon, pancreas and small intestine. It is weakly expressed in normal colon and stomach and strongly expressed in most colorectal tumors than in normal colon. It is also preferentialy expressed in mucinous tumors and in some cases neuro-endocrine tumors. REG4 protein overexpression is associated with an unfavorable response to preoperative chemoradiotherapy and may be used as a predictive biomarker clinically. REG4 is also a promising tumor marker to screen early-stage Pancreatic ductal adenocarcinoma (PDAC), and neutralization of REG4 by the antibody may offer novel potential tools for the treatment of PDAC.

參考文獻

Hartupee JC. et al., 2001, Biochim Biophys Acta. 1518: 287-93.
Violette S. et al., 2003, Int J Cancer 103: 185-93.
Kaemaeraeinen M. et al., 2003, Am J Pathol. 163: 11-20.
Takehara A. et al., 2006, Cancer Sci. 97 (11): 1191-7.
Eguchi H. et al., 2009, Pancreas. 38 (7): 791-8.

規(guī)格：50ug

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