N-Cadherin / CD325 / CDH2蛋白產(chǎn)品信息

別名: CDH2, CDHN, NCAD
表達(dá)方式: 
A DNA sequence encoding the human CDH2 (NP_001783.2) ( Met 1-Ala 724) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
種屬: Human
表達(dá)宿主: Human Cells

N-Cadherin / CD325 / CDH2 Protein QC Testing

純度: > 70 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測N端: Asp 160
分子量: 
The secreted recombinant human CDH2 is a disulfide-linked homodimeric protein. The reduced monomer comprises 813 amino acids and has a predicted molecular mass of 89.9 kDa. As a result of glycosylation, it migrates as an approximately 114 and 119 kDa band in SDS-PAGE under reducing conditions due to glycosylation.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

N-Cadherin / CD325 / CDH2 Protein Usage Guide

儲(chǔ)存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

N-Cadherin / CD325 / CDH2蛋白背景綜述

Cadherins are calcium dependent cell adhesion proteins, and they preferentially interact with themselves in a homophilic manner in connecting cells. Human cadherin 2, type 1, N-cadherin (neuronal) (NCAD) , also known as CDH2, is a single-pass tranmembrane protein and a cadherin containing 5 cadherin domains. N-cadherin displays a ubiquitous expression pattern but with different expression levels between endocrine cell types. CDH2 (NCAD) has been shown to play an essential role in normal neuronal development, which is implicated in an array of processes including neuronal differentiation and migration, and axon growth and fasciculation. In addition, N-cadherin expression was upregulated in human HSC during activation in culture, and function or expression blocking of N-cadherin promoted apoptosis. During apoptosis, N-cadherin was cleaved into 20-100 kDa fragments. N-cadherin cleavage occurred at a higher level in glioblastoma cells than in non-neoplastic astrocytes.

參考文獻(xiàn)

LaMora A. et al., 2009, Neuroscience. 159: 1175-84.
Chauvet N. et al., 2009, J Endocrinol. 202: 375-87.
Hartland SN. et al., 2009, Liver Int. 29: 966-78.
Kohutek ZA. et al., 2009, J Neurosci. 29: 4605-15.

規(guī)格：50ug

關(guān) 鍵 詞：N-Cadherin / CD325 / CDH2 Protein，廠家現(xiàn)貨，參數(shù)，實(shí)驗(yàn)室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實(shí)驗(yàn)儀器，廠家

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