CD133 / PROM1 / Prominin 1蛋白產(chǎn)品信息

別名: PROM1
表達(dá)方式: A DNA sequence encoding the rat PROM1 (F1MAN1) (Asn171-Tyr424) was expressed with a polyhistidine tag at the N-terminus.
種屬: Rat
表達(dá)宿主: Human Cells

CD133 / PROM1 / Prominin 1 Protein QC Testing

純度: > 90 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測(cè)N端: His
分子量: 
The recombinant rat PROM1 comprises 274 amino acids and predicts a molecular mass of 30.9 kDa. The apparent molecular mass of  the recombinant protein is approximately 47-57 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CD133 / PROM1 / Prominin 1 Protein Usage Guide

儲(chǔ)存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD133 / PROM1 / Prominin 1蛋白背景綜述

CD133, also known as PROM1 and Prominin 1, is a pentaspan transmembrane glycoprotein which belongs to the prominin family. It localizes to membrane protrusions and is often expressed on ***** stem cells. CD133 is known to play a role in maintaining stem cell properties by suppressing differentiation. CD133 binds cholesterol in cholesterol-containing plasma membrane microdomains. It is proposed to play a role in apical plasma membrane organization of epithelial cells. CD133 is also involved in regulation of MAPK and Akt signaling pathways. Mutations in PROM1 gene have been shown to result in retinitis pigmentosa and Stargardt disease. PROM1 gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Expression of this gene is also associated with several types of cancer.

參考文獻(xiàn)

Corbeil D. et al., 2001, Biochem Biophys Res Commun. 285 (4): 939-44.
Horn PA. et al., 1999, Blood. 93 (4): 1435-37.
Sanai N. et al., 2005, N Engl J Med. 353 (8): 811-22.

規(guī)格：20ug

關(guān) 鍵 詞：Rat CD133 / PROM1 / Prominin 1 Protein,廠家現(xiàn)貨,參數(shù)，實(shí)驗(yàn)室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實(shí)驗(yàn)儀器，廠家

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