IFNG / Interferon Gamma蛋白產(chǎn)品信息

別名: IFNG
表達(dá)方式: 
A DNA sequence encoding the ferret IFNG (A4PIZ9) (Met1-Lys166) was expressed with a polyhistidine tag at the C-terminus.
種屬: Ferret
表達(dá)宿主: Human Cells

IFNG / Interferon Gamma Protein QC Testing

純度: (43.0+47.1+9.3) % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測N端: Gln 24
分子量: 
The recombinant Ferret IFNG consists of 154 amino acids and has a calculated molecular mass of 18.4 kDa. The apparent molecular mass of the recombinant protein is approximately 28,23 and 19 KDa in SDS-PAGE under reducing conditions due to glycosylation.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

IFNG / Interferon Gamma Protein Usage Guide

儲(chǔ)存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IFNG / Interferon Gamma蛋白背景綜述

The protein IFN-γR1 (IFNGR1) is the ligand-binding chain(alpha) of the high-affinity interferon gamma receptor complex which is a heterodimer of IFN-γ R1 (IFN-γ Rα) and IFN-γ R2 (IFN-γ Rβ). IFN-γ R1 is necessary and sufficient for IFN-γ binding and receptor internalization, whereas IFN-γ R2 is required for IFN-γ signal transduction, but does not bind IFN-γ by itself. IFN-γ R1 is constitutively expressed in most cell types and soluble IFN-γ R1 has been detected in biological fluids. Human IFN-γ R1 cDNA encodes a 499 aa residue protein consisting of a 17 aa signal peptide, a 228 aa extracellular domain, a 23 aa transmembrane domain, and a 221 aa intracellular domain. Upon binding to IFN-γ receptor via its C-terminus, the type II interferon IFN gamma triggers multiple intracellular signalling processes including prevention of viral replication, inhibition of cell growth, modulation of cell differentiation, and induction of growth arrest at mid-G1 in different mammary carcinoma cell lines. A genetic variation or deficiency in IFN-γR1 is associated with susceptibility to Helicobacter pylori infection or mycobacterial disease.

參考文獻(xiàn)

Greenlund AC. et al., 1994, EMBO J. 13: 1591-600.
Bach EA. et al., 1997, Annu Rev Immunol. 15: 563-91.
Szente BE. et al., 1994, Biochem Biophys Res Commun. 203: 1645-54.
Schroder K. et al., 2004, J Leukoc Biol. 75:163-89.

規(guī)格：50ug

關(guān) 鍵 詞：Ferret IFNG / Interferon Gamma Protein，廠家現(xiàn)貨，報(bào)價(jià)，實(shí)驗(yàn)室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實(shí)驗(yàn)儀器，廠家

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