CTRL-1 / CTRL / Chymotrypsin-like protease蛋白產品信息

別名: CTRL, CTRL1
表達方式: 
A DNA sequence encoding the human CTRL (P40313) (Met1-Asn264) was expressed with a polyhistidine tag at the C-terminus.
種屬: Human
表達宿主: Human Cells

CTRL-1 / CTRL / Chymotrypsin-like protease Protein QC Testing

純度: (36.0+62.4)% as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Cys 19
分子量: 
The recombinant human CTRL consists of  257 amino acids and predicts a molecular mass of 27.6 KDa. It migrates as an approximately 35 and 32KDa band in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CTRL-1 / CTRL / Chymotrypsin-like protease Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CTRL-1 / CTRL / Chymotrypsin-like protease蛋白背景綜述

CTRL-1, also known as chymotrypsin-like protease, belongs to the peptidase S1 family. CTRL-1 contains 1 peptidase S1 domain. Its expression is increased in preeclampsia (PE). Placental-derived chymotrypsin-like protease is responsible for inducing endothelial inflammatory phenotypic changes possibly by upregulation of cell adhesion molecule expressions, activation of cellular protease, and induction of extracellular regulated kinase phosphorylation. Activated microglia have been observed in various neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, and multiple sclerosis. Five structurally distinct inhibitors that are known to inhibit chymotrypsin-like proteases were partially protective. They might represent a novel class of drugs with benefit in diseases where overactivity of microglia contributes to the pathogenesis.

參考文獻

Yang Gu. et al., 2009, Reprod Sci. 16 (9): 905-13.
Klegeris A. et al., 2005, Glia. 51 (1):56-64.
Caroline V. Bamford. et al., 2007, nfect Immun. 75 (9): 4364-72.

規(guī)格：20ug

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