CD23 / FCER2 / FCER2A蛋白產(chǎn)品信息

別名: FCER2, Fcer2a
表達(dá)方式: 
A DNA sequence encoding the rat FCER2 (Q6AZ45) (Glu50-Pro331) was expressed with Fc region of human IgG1 at the N-terminus.
種屬: Rat
表達(dá)宿主: Human Cells

CD23 / FCER2 / FCER2A Protein QC Testing

純度: > 90 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測N端: Glu
分子量: 
The recombinant rat FCER2 comprises 542 amino acids and predicts a molecular mass of 60.2 kDa. The apparent molecular mass of  the recombinant protein is approximately 61 kDa in SDS-PAGE under reducing conditions due to glycosylation.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CD23 / FCER2 / FCER2A Protein Usage Guide

儲(chǔ)存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD23 / FCER2 / FCER2A蛋白背景綜述

Low affinity immunoglobulin epsilon Fc receptor, also known as BLAST-2, C-type lectin domain family 4 member J, Fc-epsilon-RII, Immunoglobulin E-binding factor, Lymphocyte IgE receptor, CD23 and FCER2, is a secreted and single-pass type II membrane protein which is also exists as a soluble excreted form. There are two forms of CD23: CD23a and CD23b. CD23a is present on follicular B cells, whereas CD23b requires IL-4 to be expressed on T-cells, monocytes, Langerhans cells, eosinophils, and macrophages. Unlike many of the antibody receptors, CD23 / FCER2 is a C-type lectin. It is found on mature B cells, activated macrophages, eosinophils, follicular dendritic cells, and platelets. In flow cytometry, CD23 / FCER2 is helpful in the differentiation of chronic lymphocytic leukemia (CD23-positive) from mantle cell leukemia (CD23-negative). CD23 / FCER2 can also be demonstrated in germinal centre B-cells using immunohistochemistry, but it is not present in the resting cells of the surrounding mantle zone. CD23 / FCER2 has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

參考文獻(xiàn)

Kikutani H. et al., 1986, Cell. 47: 657-65.
Rose K. et al., 1992, Biochem J. 286: 819-24.
Padlan EA. et al., 1993, Receptor. 3: 325-41.
Bajorath J. et al., 1996, Protein Sci. 5: 240-247.
Barna G. et al., 2008, Hematol Oncol. 26 (3): 167-70.

規(guī)格：50ug

關(guān) 鍵 詞：Rat CD23 / FCER2 / FCER2A Protein,廠家現(xiàn)貨,報(bào)價(jià)，實(shí)驗(yàn)室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實(shí)驗(yàn)儀器，廠家

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