STX8 / Syntaxin 8蛋白產(chǎn)品信息

別名: STX8
表達方式: 
A DNA sequence encoding the human STX8 (Q9UNK0) (Met1-Gly215) was expressed with an N-terminal polyhistidine tag.
種屬: Human
表達宿主: Human Cells

STX8 / Syntaxin 8 Protein QC Testing

純度: > 85 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: His
分子量: 
The recombinant human STX8 comprises 235 amino acids and has a predicted molecular mass of 27 kDa. The apparent molecular mass of the protein is approximately 34 kDa in SDS-PAGE under reducing conditions due to glycosylation.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

STX8 / Syntaxin 8 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

STX8 / Syntaxin 8蛋白背景綜述

STX8, also known as syntaxin 8, directly interacts with HECTd3. STX8 forms the SNARE complex with syntaxin 7, vti1b and endobrevin. STX8 belongs to the syntaxin family. Members of this family are key molecules implicated in diverse vesicle docking and membrane fusion events. STX8 physically interacts with cystic fibrosis transmembrane conductance regulator (CFTR): recombinant syntaxin 8 binds CFTR in vitro and both proteins co-immunoprecipitate in HT29 cells. Syntaxin 8 regulates CFTR-mediated currents in chinese hamster ovary (CHO) cells stably expressing CFTR and syntaxin 8. STX8 contributes to the regulation of CFTR trafficking and chloride channel activity by the SNARE machinery.

參考文獻

Steegmaier M. et al., 1999, J Biol Chem. 273 (51): 34171-9.
Thoreau V. et al., 1999, Biochem Biophys Res Commun. 257 (2): 577-83.
Zhang L. et al., 2009, Cell Mol Neurobiol. 29 (1): 115-21.
Bilan F. et al., 2004, J Cell Sci. 117 (10): 1923-35.

規(guī)格：50ug

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