BTC / Betacellulin蛋白產品信息

別名: BTC
表達方式: 
A DNA sequence encoding the cynomolgus BTC (XP_001101880.1) (Met1-Tyr111) was expressed with the Fc region of human IgG1 at the C-terminus.
種屬: Cynomolgus
表達宿主: Human Cells

BTC / Betacellulin Protein QC Testing

純度: > 85 % as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Asp 32
分子量: 
The recombinant cynomolgus BTC is a disulfide-linked homodimer. The reduced monomer comprises 321 amino acids and has a calculated molecular mass of 36 KDa.The apparent molecular mass of the protein is approximately 46 KDa respectively in SDS-PAGE.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

BTC / Betacellulin Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

BTC / Betacellulin蛋白背景綜述

Probetacellulin, also known as Betacellulin and BTC is a single-pass type I membrane protein. Betacellulin is synthesized in several tissues and tumor cells. It is predominantly expressed in pancreas and small intestine. The expression of Betacellulin is particularly high in the pancreas where it is thought to play a role in the differentiation of pancreatic beta cells. Betacellulin belongs to the epidermal growth factor (EGF) family of peptide ligands that are characterised by a six-cysteine consensus motif that forms three intra-molecular disulfide bonds crucial for binding the ErbB receptor family. Betacellulin was initially described, purified and cloned from a mouse insulinoma cell line. It is proteolytically processed from a larger membrane-anchored precursor and is a potent mitogen for a wide variety of cell types. Betacellulin binds and activates ErbB-1 and ErbB-4 homodimers. Betacellulin stimulated gastrointestinal growth, the increased responsiveness of the terminal ileum and colon suggesting therapeutic potential in disease conditions in which ileal or colonic re-growth is desirable. Betacellulin further stimulated a diuresis suggesting an additional role in fluid homeostasis.

參考文獻

Dunbar AJ. et al., 2000, Int J Biochem Cell Biol. 32 (8): 805-15.
Howarth GS. et al., 2003, Growth Factors. 21 (2): 79-86.
Moon WS. et al., 2006, Hum Pathol. 37 (10): 1324-32.
Mummery RS. et al., 2007, Glycobiology. 17 (10): 1094-103.
Dunbar AJ. et al., 2001, J Mol Endocrinol. 27 (2): 239-47.

規(guī)格：10ug

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