LTBR蛋白產(chǎn)品信息

別名: LTBR
表達(dá)方式: 
A DNA sequence encoding the rat LTBR (Q5U2S8) (Met1-Ala218) was expressed with the Fc region of human IgG1 at the C-terminus.
種屬: Rat
表達(dá)宿主: Human Cells

LTBR Protein QC Testing

純度: (9.8+79.7) % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測N端: Ser 28
分子量: 
The recombinant rat LTBR/Fc is a disulfide-linked homodimer. The reduced monomer comprises 432 amino acids and has a predicted molecular mass of 48.5 kDa. The apparent molecular mass of the protein is approximately 66 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

LTBR Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

LTBR蛋白背景綜述

LTBR (lymphotoxin beta receptor (TNFR superfamily, member 3)) contains 4 TNFR-Cys repeats and belongs to the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. It is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs. LTBR has been shown to interact with diablo homolog and TRAF3. It can lead to the release of the cytokine interleukin 8. Overexpression of LTBR in HEK293 cells increases IL-8 promoter activity and leads to IL-8 release. LTBR is also essential for development and organization of the secondary lymphoid organs and chemokine release. It specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and transformed cells.

參考文獻(xiàn)

Summers deLuca L. et al., 2011, Proc Natl Acad Sci. 108 (5): 2046-51.
Bista P. et al., 2010, J Biol Chem. 285 (17): 12971-8.
Xu Y. et al., 2011, Biochem Biophys Res Commun. 404 (4): 1060-4.

規(guī)格：50ug

關(guān) 鍵 詞：Rat LTBR Protein,技術(shù)資料,廠家,現(xiàn)貨，實驗室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實驗儀器，廠家

CANSPEC品質(zhì)提供的Rat LTBR Protein|技術(shù)資料|廠家|現(xiàn)貨性能**，其優(yōu)良的品質(zhì)滿足您不同實驗的多種需求。

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