LILRB2 / ILT4 / LIR-2蛋白產(chǎn)品信息

別名: LILRB2, ILT4, LIR2, MIR10
表達方式: 
A DNA sequence encoding the human LILRB2 (AAH36827.1) (Met1-Val461) was expressed with the Fc region of human IgG1 at the C-terminus.
種屬: Human
表達宿主: Human Cells

LILRB2 / ILT4 / LIR-2 Protein QC Testing

純度: > 85 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Gln 22
分子量: 
The recombinant human LILRB2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 681 amino acids and has a predicted molecular mass of 74.8 kDa. The apparent molecular mass of the protein is approximately 93 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

LILRB2 / ILT4 / LIR-2 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

LILRB2 / ILT4 / LIR-2蛋白背景綜述

ILT4, also known as LILRB2, is a member of the the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). ILT4 gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. Multiple transcript variants encoding different isoforms have been found for ILT4 gene. ILT4 is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity.

參考文獻

Fanger NA. et al., 1998, Eur J Immunol. 28 (11): 3423-34.
Willcox BE. et al., 2003, BMC Struct Biol. 2: 6.
Chang CC. et al., 2002, Nat Immunol. 3 (3): 237-43.

規(guī)格：50ug

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