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Rat TrkA / NTRK1 Protein|技術(shù)資料|現(xiàn)貨

產(chǎn)品名稱(chēng): Rat TrkA / NTRK1 Protein|技術(shù)資料|現(xiàn)貨
產(chǎn)品型號(hào): C86-804-04
產(chǎn)品展商: 博飛美科
產(chǎn)品文檔: 無(wú)相關(guān)文檔

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Rat TrkA / NTRK1 Protein|技術(shù)資料|現(xiàn)貨由上海創(chuàng)賽科學(xué)儀器有限公司品質(zhì)提供,可查詢(xún)Rat TrkA / NTRK1 Protein價(jià)格。上海創(chuàng)賽科學(xué)儀器有限公司是專(zhuān)業(yè)**試劑生產(chǎn)及供應(yīng)商,其優(yōu)良的品質(zhì)滿(mǎn)足您不同實(shí)驗(yàn)的多種需求,歡迎撥打4006087598洽談選購(gòu),更多產(chǎn)品詳情請(qǐng)登錄www.ahbcpqn.cn


Rat TrkA / NTRK1 Protein|技術(shù)資料|現(xiàn)貨  的詳細(xì)介紹

TrkA / NTRK1蛋白產(chǎn)品信息

別名: NTRK1, Trk, Trka
表達(dá)方式: 
A DNA sequence encoding the rat NTRK1 (P35739-Isoform TrkA-II)(Met1-Pro418) was expressed with the Fc region of human IgG1 at the C-terminus.
種屬: Rat
表達(dá)宿主: Human Cells

TrkA / NTRK1 Protein QC Testing

純度: > 95% as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測(cè)N端: Ala 33
分子量: 
The recombinant rat NTRK1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 627 amino acids and has a predicted molecular mass of 69.2 kDa. The apparent molecular mass of the protein is approximately 92-102 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

TrkA / NTRK1 Protein Usage Guide

儲(chǔ)存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TrkA / NTRK1蛋白背景綜述

Neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), also well known as TrkA, is a member of the neurotrophic tyrosine kinase receptor family belonging to Tyr protein kinase superfamily, which also includes TrkB and TrkC. TrkA/NTRK1 has a complex subdomain orgnazation conserved in the family members, containing two cysteine-rich domains, a cluster of three leucine-rich motifs (LRR), and two Ig-like C2-type domains in the extracellular region, as well as an tyrosine kinase domain in the cytoplasmic region. TrkA/NTRK1 exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures, and is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). TrkA/NTRK1 plays an important role in cell survival, differentiation, and apoptosis in various neuronal and nonneuronal cell types, especially in the nervous system by recruiting signaling molecules including SHC1, PI 3-kinase, and PLC-gamma-1 that activate pathways required for the growth and survival of neurons. It has been shown that TrkA/NTRK1 is specially involved in the development and function of the nociceptive reception system and establishment of thermal regulation via sweating. Two distinct TrkA/NTRK1 isoforms have been identified: TrkA-II is primarily expressed in neuronal cells, while isoform TrkA-I is found in non-neuronal tissues. Defects in TrkA/NTRK1 are a cause of a rare autosomal recessive disorder, congenital insensitivity to pain with anhidrosis (CIPA).

參考文獻(xiàn)

Bossemeyer D. et al., 1989, J Biol Chem. 264: 16403-10.
Varsano T. et al., 2006 , Mol Cell Biol. 26: 8942-52.
Perrone L. et al., 2005, Biochem J. 385: 233-41.
Holtzman DM. et al., 2009 , J Neurosci. 15: 1567-76.
Dan C Lin. et al., 2006,Mol Cell Biol. 26: 8928-41.
Jung EJ. et al., 2008, Exp Mol Med. 40: 276-85.

規(guī)格:50ug

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