PSGL-1 / CD162 / SELPLG蛋白產(chǎn)品信息

別名: SELPLG
表達方式: 
A DNA sequence encoding the human SELPLG (Q14242) (Met1-Gly295) with a C-terminal polyhistidine tag was expressed.
種屬: Human
表達宿主: Human Cells

PSGL-1 / CD162 / SELPLG Protein QC Testing

純度: (82+15.2)% as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測N端: Leu 18
分子量: 
The recombinant human SELPLG comprises 289 amino acids and has a predicted molecular mass of 30.5 kDa. The apparent molecular mass of the protein is approximately 89 and 61 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

PSGL-1 / CD162 / SELPLG Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

PSGL-1 / CD162 / SELPLG蛋白背景綜述

P-selectin glycoprotein ligand-1 (PSGL-1), also known as SELPLG or CD162, is the high affinitycounter-receptor for P-selectin on expressed on activated endothelial cells and platelets. PSGL-1 is a mucin-type glycoprotein, expressed on leukocytes and platelets as a homodimer of two disulfide-linked subunits of ~120 kD. As cell adhesion molecules, multiple studies have shown that PSGL-1/ P-selectin interaction is required for the normal recruitment of leukocytes during inflammatory reactions, and also participates in hemostatic responses. PSGL-1 protein requires two distinct posttranslational modifications for the Ca2+-dependent recognition by the lectin domain of P-selectin, that is tyrosine sulfation and specific O-linked glycosylation (sialic acid and fucose). PSGL-1 can also bind to other two members of the selectin family, E-selectin (endothelial) and L-selectin (leukocyte), but binds best to P-selectin.

參考文獻

Sako D. et al., 1993, Cell. 75: 1179-86.
Wilkins P P. et al., 1995, J Biol Chem. 270: 22677-80.
Frenette P S. et al., 2000, J Exp Med. 191: 1413-22.
Vandendries ER .et al., 2004, Thromb Haemost. 92: 459-66.
Pouyani T. et al., 1995, Cell. 83: 333-43.

規(guī)格：50ug

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