IL1R1 / CD121a蛋白產(chǎn)品信息

別名: IL1R1
表達方式: 
A DNA sequence encoding the human IL1R1 (NP_000868.1) (Met1-Thr332) was expressed with five amino acids (DDDDK) at the C- terminus was expressed and purified.
種屬: Human
表達宿主: Human Cells

IL1R1 / CD121a Protein QC Testing

純度: > 90% as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Leu 18
分子量: 
The recombinant human IL1R1 consists of  321 amino acids and predicts a molecular mass of 36.8 KDa. It migrates as an approximately 56 KDa band in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

IL1R1 / CD121a Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL1R1 / CD121a蛋白背景綜述

Interleukin 1 receptor, type I (IL1R1), also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor that belongs to the IL-1 receptor family. IL1R1 is a receptor for both interleukin alpha (IL1A) and interleukin beta (IL1B), and also associates with interleukin-1 receptor antagonist protein (IL-1RA). There are two distinct types of receptors that bind the pleiotropic cytokines IL1A and IL1B: the type I is an 80 kDa transmembrane protein expressed predominantly by T cells, fibroblasts, and endothelial cells and appears to mediate all the known IL-1 biological functions. However, the type a… receptor is a 68 kDa transmembrane protein with a short cytoplamic domain and serves as a decoy for IL-1. IL1R1 structurally consists of three C2-type I g-like domains and one TIR domain. As important mediators involved in many immune and inflammatory responses, the agonists IL1A and IL1B bind to IL1R1, leading to the signal transduction and activation of NF-kappa-B. Formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2 is indepensible for the signaling processes. Recombinant soluble form of IL1R1 is thus a potent antagonist of IL-1 function.

參考文獻

Reddy SA. et al., 1997, J Biol Chem. 272 : 29167-73.
Huang J. et al.,1997, Proc. Natl Acad Sci. 94: 12829-32.
Vigers G PA. et al., 1997, Nature. 386:190-4.
Schreuder H. et al., 1997, Nature. 386:194-200.
Vigers GPA. et al., 2000, J Biol Chem. 275: 36927-33.

規(guī)格：50ug

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