FAS / TNFRSF6 / CD95蛋白產(chǎn)品信息

別名: FAS, Apt1, Tnfrsf6
表達(dá)方式: 
A DNA sequence encoding the rat FAS (NP_631933.2) (Met1-Lys170) was expressed with the Fc region of human IgG1 at the C-terminus.
種屬: Rat
表達(dá)宿主: Human Cells

FAS / TNFRSF6 / CD95 Protein QC Testing

純度: (73+25)% as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測(cè)N端: Gln 22
分子量: 
The recombinant rat FAS/Fc is a disulfide-linked homodimer. The reduced monomer comprises 390 amino acids and has a predicted molecular mass of 43.7 kDa. The apparent molecular mass of the protein is approximately 57 and 36 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

FAS / TNFRSF6 / CD95 Protein Usage Guide

儲(chǔ)存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

FAS / TNFRSF6 / CD95蛋白背景綜述

Tumor necrosis factor receptor superfamily member 6, also known as Apoptosis-mediating surface antigen FAS, FASLG receptor, FAS, and CD95, is a member of the tumor necrosis factor (TNF) / nerve growth factor (NGF) receptor superfamily. FAS is highly expressed on the surface of a number of cell types including epithelial cells, hepatocytes, activated mature lymphocytes and other tumor cells. This receptor contains a death domain and has been shown to play a central role in the physiological regulation of programmed cell death (PCD, apoptosis) upon ligation of Fas ligand (Fas-L). This FAS receptor has been reported to be involved in the activation of NF-kappaB, MAPK3 / ERK1, MAPK8 / JNK, and the alternate pathways for CTL-mediated cytotoxicity. Accordingly, FAS is implicated in the pathogenesis of various malignancies and diseases of the immune system. Multiple Fas isoforms are derived from alternative spliced transcript variants, and among which, a soluble form lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoforms.

參考文獻(xiàn)

Suda T. et al., 1993, Cell. 75: 1169-78.
Cascino I. et al., 1995, J Immunol. 154: 2706-13.
Brunner T. et al., 1995, Nature. 373: 441-4.
Hirata H. et al., 1998, J Exp Med. 187: 587-600.
Mary M. et al., 2001, J Biol Chem. 276: 4964-71.
Milhas D. et al., 2005, J Biol Chem. 280 :19836-42.

規(guī)格：50ug

關(guān) 鍵 詞：Rat FAS / TNFRSF6 / CD95 Protein,技術(shù)資料,價(jià)格，實(shí)驗(yàn)室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實(shí)驗(yàn)儀器，廠家

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