GHR / Growth Hormone Receptor蛋白產(chǎn)品信息

別名: GHR
表達(dá)方式: 
A DNA sequence encoding the rat GHR (P16310-1) (Met1-Arg265) was expressed with the Fc region of human IgG1 at the C-terminus.
種屬: Rat
表達(dá)宿主: Human Cells

GHR / Growth Hormone Receptor Protein QC Testing

純度: > 95 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測N端: Phe 19
分子量: 
The recombinant rat GHR/Fc is a disulfide-linked homodimer. The reduced monomer comprises 488 amino acids and has a predicted molecular mass of 55.4 kDa. The apparent molecular mass of the protein is approximately 66 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

GHR / Growth Hormone Receptor Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

GHR / Growth Hormone Receptor蛋白背景綜述

Growth hormone receptor, also known as GH receptor, Somatotropin receptor and GHR, is a single-pass type I  membrane protein which belongs to the type I  cytokine receptor family and type 1 subfamily. GHR contains one fibronectin type-III domain. Growth hormone receptor / GHR is expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 of GHR is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression of GHR in placenta is predominant in chorion and decidua. Isoform 4 is highly expressed in placental villi. Isoform 2 of GHR is expressed in lung, stomach and muscle. Growth hormone receptor / GHR is a receptor for pituitary gland growth hormone. It is involved in regulating postnatal body growth. On ligand binding, it couples to the JAK2 / STAT5 pathway. Isoform 2 of GHR up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. Defects in GHR are a cause of Laron syndrome (LARS) which is a severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. Defects in GHR may also be a cause of idiopathic short stature autosomal (ISSA) which is defined by a subnormal rate of growth.

參考文獻(xiàn)

Leung DW. et al., 1987, Nature. 330:537-43.
Sobrier M-L. et al., 1997, J Clin Endocrinol Metab. 82: 435-7.
Enberg B. et al., 2000, Eur J Endocrinol. 143: 71-6.
Pantel J. et al., 2000, J Biol Chem. 275: 18664-9.
Jorge AAL. et al., 2004, Clin Endocrinol. (Oxf.) 60: 36-40.

規(guī)格：50ug

關(guān) 鍵 詞：Rat GHR / Growth Hormone Receptor Protein,參數(shù),價格，實驗室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實驗儀器，廠家

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