GPNMB / Osteoactivin蛋白產(chǎn)品信息

別名: GPNMB, NMB, HGFIN
表達(dá)方式: 
A DNA sequence encoding the human GPNMB (Q14956-2) (Met1-Pro474) was expressed with the Fc region of human IgG1 at the C-terminus.
種屬: Human
表達(dá)宿主: Human Cells

GPNMB / Osteoactivin Protein QC Testing

純度: > 95 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測(cè)N端: Ala 22
分子量: 
The recombinant human GPNMB/Fc is a disulfide-linked homodimer. The reduced monomer comprises 694 amino acids and has a predicted molecular mass of 77.8 kDa. The apparent molecular mass of the protein is approximately 114 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

GPNMB / Osteoactivin Protein Usage Guide

儲(chǔ)存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

GPNMB / Osteoactivin蛋白背景綜述

GPNMB belongs to the PMEL / NMB family, also known as Osteoactivin and Hematopoietic growth factor-inducible neurokinin 1 ( HGFIN ), is a transmembrane glycoprotein that is expressed in numerous cells, including osteoclasts, macrophages, dendritic cells, and tumor cells. It is suggested to influence osteoblast maturation, cell adhesion and migration. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages. Osteoactivin is expressed at high levels in normal and inflammatory liver macrophages suggesting a significant role in acute liver injury. The early-phase upregulation of Osteoactivin expression in the tubular epithelium in response to renal injury might play a role in triggering renal interstitial fibrosis via activation of matrix metalloproteinase expression and collagen remodeling in rats. Osteoactivin as a protein that is expressed in aggressive human breast cancers and is capable of promoting breast cancer metastasis to bone.

參考文獻(xiàn)

Pahl MV. et al., 2010, Clin J Am Soc Nephrol. 5 (1): 56-61.
Abdelmagid SM. et al., 2008, Exp Cell Res. 314 (13): 2334-51.
Haralanova-Ilieva B. et al., 2005, J Hepatol. 242 (4): 565-72.
Abdelmagid SM. et al., 2007, J Cell Physiol. 210 (1): 26-37.
Furochi H. et al., 2007, J Med Invest. 54 (3-4): 248-54.

規(guī)格：50ug

關(guān) 鍵 詞：GPNMB / Osteoactivin Protein,現(xiàn)貨,產(chǎn)品詳情，實(shí)驗(yàn)室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實(shí)驗(yàn)儀器，廠家

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