IL10RA蛋白產(chǎn)品信息

別名: IL10RA
表達(dá)方式: 
A DNA sequence encoding the cynomolgus IL10RA(Thr9-Asn245) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
種屬: Cynomolgus
表達(dá)宿主: Human Cells

IL10RA Protein QC Testing

純度: > 95 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測(cè)N端: Phe 29
分子量: 
The recombinant cynomolgus IL10RA is a disulfide-linked homodimer. The reduced monomer comprises 458 amino acids and has a calculated molecular mass of 51.8 KDa.The apparent molecular mass of the protein is approximately 62-66 KDa respectively in SDS-PAGE.
緩沖液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

IL10RA Protein Usage Guide

儲(chǔ)存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL10RA蛋白背景綜述

CD219, also known as IL10RA, is a subunit for the interleukin-10 receptor. IL10RA has also recently been designated CDW210A (cluster of differentiation W210A). It is structurally related to interferon receptors. CD219 has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. It has been reported that CD219 promotes survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of CD219 leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.

參考文獻(xiàn)

Josephson K. et al., 2001, Acta Crystallogr D Biol Crystallogr. 57 (12): 1908-11.
Tan J C. et al., 1995, J Biol Chem. 270 (21): 12906-11.
Josephson K. et al., 2001, Immunity. 15 (1): 35-46.

規(guī)格：50ug

關(guān) 鍵 詞：Cynomolgus IL10RA Protein,技術(shù)資料,價(jià)格，實(shí)驗(yàn)室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實(shí)驗(yàn)儀器，廠家

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