DDR1蛋白產(chǎn)品信息

別名: DDR1
表達方式: 
A DNA sequence encoding the rat DDR1 (Q6MG19)(Met1-Thr413) was expressed with a polyhistidine tag at the C-terminus.
種屬: Rat
表達宿主: Human Cells

DDR1 Protein QC Testing

純度: > 95 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測N端: Asp 20
分子量: 
The recombinant rat DDR1 comprises 405 amino acids and predicts a molecular mass of 45.3 kDa. The apparent molecular mass of  the recombinant protein is approximately 52 kDa in SDS-PAGE under reducing conditions due to glycosylation.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

DDR1 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

DDR1蛋白背景綜述

Epithelial discoidin domain-containing receptor 1, also known as Tyrosine kinase DDR, Discoidin receptor tyrosine kinase, CD167a, and DDR1, is a single-pass type I  membrane protein. It belongs to the protein kinase superfamily and insulin receptor subfamily. DDR1 contains one F5/8 type C domain and one protein kinase domain. DDR1 is expressed at low levels in most ***** tissues and is highest in the brain, lung, placenta and kidney. Lower levels of expression are detected in melanocytes, heart, liver, skeletal muscle and pancreas. DDR1 is abundantly expressed in breast carcinoma cell lines. DDR1 regulates cell adhesion and a broad range of cell behavior. DDR1 plays an important role as a collagen receptor, mediating intimal thickening after vascular injury. DDR1 and DDR2 are tyrosine kinase receptors activated by triple-helical collagens. Aberrant expression and signaling of these receptors have been implicated in several human diseases linked to accelerated matrix degradation and remodeling including tumor invasion, atherosclerosis and liver fibrosis.

參考文獻

Hou G. et al., 2001, J Clin Invest. 107 (6): 727-35.
Abdulhussein R. et al., 2004, J Biol Chem. 279 (30): 31462-70.
Mihai C. et al., 2009, J Mol Biol. 385 (2): 432-45.
Wang CZ. et al., 2009, Am J Physiol Cell Physiol. 297 (2): C419-29.
Flynn LA. et al., 2010, J Mol Biol. 395 (3): 533-43.

規(guī)格：50ug

關(guān) 鍵 詞：Rat DDR1 Kinase / MCK10 / CD167 Protein,參數(shù),技術(shù)資料，實驗室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實驗儀器，廠家

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