DCIR / CLEC4A2蛋白產(chǎn)品信息

別名: CLEC4A2, Dcir2
表達(dá)方式: 
A DNA sequence encoding the rat CLEC4A2 (Q5YIS1) (Gln70-Ser235) was expressed with a polyhistidine tag at the N-terminus.
種屬: Rat
表達(dá)宿主: Human Cells

DCIR / CLEC4A2 Protein QC Testing

純度: > 95 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測(cè)N端: His
分子量: 
The recombinant rat CLEC4A2 comprises 186 amino acids and has a predicted molecular mass of 21.8 kDa. The apparent molecular mass of the protein is approximately 32-36 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

DCIR / CLEC4A2 Protein Usage Guide

儲(chǔ)存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

DCIR / CLEC4A2蛋白背景綜述

DCIR, also known as CLEC4A2, is a member of the subfamily of cell surface C-type lectin receptors (CLR), whose multifunctional capacities range from classical Ag uptake and immunoregulatory mechanisms to the involvement in dendritic cell (DC) ontogeny. DCIR acts as an inhibitory receptor depending on its immunoreceptor tyrosine-based inhibitory motif. Expression of mouse DCIR mRNA was observed specifically in spleen and lymph node, slightly increased with dendritic cell maturation during in vitro culture of bone marrow cells, and was not detected in cultured natural killer cells. DCIR deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells.

參考文獻(xiàn)

Carninci P. et al., 2005, Science. 309 (5740): 1559-63.
Katayama S. et al., 2005, Science. 309 (5740): 1564-6.
Diez-Roux G. et al., 2011, PLoS Biol. 9 (1): e1000582.

規(guī)格：100ug

關(guān) 鍵 詞：Rat DCIR / CLEC4A2 Protein,現(xiàn)貨,價(jià)格，實(shí)驗(yàn)室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實(shí)驗(yàn)儀器，廠家

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