ROBO2蛋白產(chǎn)品信息

別名: ROBO2, KIAA1568
表達(dá)方式: 
A DNA sequence encoding the human ROBO2 (Q9HCK4-1) (Met1-Pro859) was expressed with a polyhistidine tag at the C-terminus.
種屬: Human
表達(dá)宿主: Human Cells

ROBO2 Protein QC Testing

純度: > 95% as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測(cè)N端: Ser 22
分子量: 
The recombinant human ROBO2 consists of  849 amino acids and predicts a molecular mass of 94.2 KDa. It migrates as an approximately 116 KDa band in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

ROBO2 Protein Usage Guide

儲(chǔ)存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

ROBO2蛋白背景綜述

ROBO2 is a member of the ROBO family. ROBOs are a group of highly conserved transmembrane glycoproteins that make up a small subgroup of the immunoglobulin (Ig) superfamily. They are best known for their roles as receptors for the Slit family of repellent axon guidance cues. In structure, they are characterized by five C2-type Ig-like repeats, three fibronectin type III domains, a transmembrane region, and an intracellular domain with three (ROBO3) or four (ROBO1, 2) CC (conserved cytoplasmic) motifs. ROBO2 abrogates SLIT-ROBO signaling in vitro. ROBO2 is a receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.

參考文獻(xiàn)

Brose K. et al., 1999, Cell. 96 (6): 795-806.
Brose K. et al., 1999, Neuron. 22 (3): 463-73.
Nagase T. et al., 2001, DNA Res. 7 (4): 273-81.

規(guī)格：50ug

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