SEMA4D / Semaphorin 4D蛋白產(chǎn)品信息

別名: SEMA4D
表達(dá)方式: 
A DNA sequence encoding the rat SEMA4D (Met1-Met712) was expressed with the Fc region of human IgG1 at the C-terminus.
種屬: Rat
表達(dá)宿主: Human Cells

SEMA4D / Semaphorin 4D Protein QC Testing

純度: > 95% as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測(cè)N端: Phe 24
分子量: 
The recombinant rat SEMA4D/Fc is a disulfide-linked homodimer. The reduced monomer comprises 930 amino acids and has a predicted molecular mass of 103.4 kDa. The apparent molecular mass of the protein is approximately 118 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

SEMA4D / Semaphorin 4D Protein Usage Guide

儲(chǔ)存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

SEMA4D / Semaphorin 4D蛋白背景綜述

Semaphorin-4D, also known as SEMA4D and CD100, is a single-pass type I  membrane protein which belongs to the semaphorin family. Semaphorin-4D / SEMA4D contains one Ig-like C2-type (immunoglobulin-like) domain, one PSI domain and one Sema domain. Semaphorin-4D / SEMA4D is strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver. Semaphorin-4D / SEMA4D may play a functional role in the immune system, as well as in the nervous system. Induces B-cells to aggregate and improves their viability. Semaphorin-4D / SEMA4D is an axon guidance molecule which is secreted by oligodendrocytes and induces growth cone collapse in the central nervous system. By binding plexin-B1 receptor it functions as an R-Ras GTPase-activating protein (GAP) and repels axon growth cones in both the mature central nervous system. In the immune system, Semaphorin-4D / SEMA4D binds CD72 to activate B cells and dendritic cells. It is involved in oligodendrogenesis during development and during recovery from ischemic injury.

參考文獻(xiàn)

Masuda,K. et al., 2004, Genes Cells. 9 (9):821-9.
Duran-Struuck R. et al., 2007, Biol Blood Marrow Transplant. 13 (11): 1294-303.
Taniguchi Y. et al., 2009, J Neurosci Res. 87 (13): 2833-41.
Ch'ng E S. et al., 2010, Mol Cancer. 9: 251.

規(guī)格：50ug

關(guān) 鍵 詞：Rat SEMA4D / Semaphorin 4D Protein,產(chǎn)品詳情,報(bào)價(jià)，實(shí)驗(yàn)室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實(shí)驗(yàn)儀器，廠家

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