F11R / JAM-A / JAM-1蛋白產(chǎn)品信息

別名: F11R, Jam1
表達(dá)方式: 
A DNA sequence encoding the rat F11R (Q9JHY1)(Met1-Gly238) was expressed with a polyhistidine tag at the C-terminus.
種屬: Rat
表達(dá)宿主: Human Cells

F11R / JAM-A / JAM-1 Protein QC Testing

純度: > (23.7+75.2) % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測(cè)N端: Lys 27
分子量: 
The recombinant rat F11Rcomprises 223 amino acids and predicts a molecular mass of 24.3 kDa. The apparent molecular mass of  the recombinant protein is approximately 28 and 32 kDa in SDS-PAGE under reducing conditions due to glycosylation.
緩沖液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

F11R / JAM-A / JAM-1 Protein Usage Guide

儲(chǔ)存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

F11R / JAM-A / JAM-1蛋白背景綜述

Junctional adhesion molecule A, also known as Junctional adhesion molecule 1, Platelet F11 receptor, JAM-1, Platelet adhesion molecule 1, JAM-A, PAM-1, CD321 and F11R, is a single-pass type I  membrane protein which belongs to the immunoglobulin superfamily and Junctional Adhesion Molecule (JAM) family. JAM-A / CD321 is the firstly identified member of the JAM family comprising at least three members. JAM-A is specifically localized in tight junctions of epithelial and endothelial cells and is involved in the regulation of junctional integrity and permeability by serving as a physical barrier in a homophilic manner. JAM-A is also expressed on the surface of hematopoeitic cells, such as platelets and leukocytes, and acts as a ligand for integrin LFA-1 or a platelet receptor, consequently plays key roles in a variety of cellular processes, including platelet aggregation, leukocyte transmigration, and angiogenesis. In addition, JAM-A has also been implicated in the attachment of reovirus that causes diarrhea.

參考文獻(xiàn)

Williams LA. et al., 1999, Mol Immunol. 36: 1175-88.
Sobocka MB. et al., 2000, Blood. 95: 2600-9.
Babinska A. et al., 2002, Thromb Haemost. 88: 843-50.
Ostermann G. et al., 2002, Nat Immunol. 3: 151-8.
Kenneth J. et al., 2005, J Biol Chem. 280: 11665-74.
Bazzoni G. et al., 2003, Curr Opin Cell Biol. 15: 525-30.
Barton ES. et al., 2001, Cell. 104 : 441-51.

規(guī)格：20ug

關(guān) 鍵 詞：Rat F11R / JAM-A / JAM-1 Protein,價(jià)格,產(chǎn)品詳情，實(shí)驗(yàn)室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實(shí)驗(yàn)儀器，廠家

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