MSLN / Mesothelin蛋白產(chǎn)品信息
別名: MSLN
表達(dá)方式:
A DNA sequence encoding the human MSLN (Q13421-2) (Met1-Arg286) was expressed with a polyhistidine tag at the C-terminus.
種屬: Human
表達(dá)宿主: Human Cells
MSLN / Mesothelin Protein QC Testing
純度: > 90% as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測(cè)N端: Leu 37
分子量:
The recombinant human MSLN consists of 261 amino acids and predicts a molecular mass of 28.2 KDa. It migrates as an approximately 33 KDa band in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
MSLN / Mesothelin Protein Usage Guide
儲(chǔ)存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
MSLN / Mesothelin蛋白背景綜述
Megakaryocyte potentiating factor is a member of the mesothelin family. This family consists of several mammalian pre-pro-megakaryocyte potentiating factor precursor (MPF) or mesothelin proteins. Both megakaryocyte potentiating factor and the cleaved form of mesothelin are N-glycosylated. Mesothelin is a tumour differentiation antigen that is normally present on the mesothelial cells lining the pleura, peritoneum and pericardium. Megakaryocyte potentiating factor is secreted by several mesothelioma cell lines and is frequently elevated in the blood of patients with mesothelioma. Measurement of this protein may be useful in following the response of mesothelioma to treatment. Megakaryocyte potentiating factor interacts with MUC16 and potentiates megakaryocyte colony formation in vitro. Its membrane-anchored forms may play a role in cellular adhesion.
參考文獻(xiàn)
Chang MC. et al., 2012, Biochem J. 442 (2): 293-302.
Nelson HH. et al., 2011, Epigenetics. 6 (8): 1029-34.
Bournet B. et al., 2012, Pancreatology. 12 (1): 27-34.
規(guī)格:50ug
關(guān) 鍵 詞:MSLN / Mesothelin Protein,廠家現(xiàn)貨,參數(shù),實(shí)驗(yàn)室耗材,生化試劑,上海創(chuàng)賽,博飛美科,實(shí)驗(yàn)儀器,廠家
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