PDGFRB / PDGFR-1蛋白產(chǎn)品信息

別名: PDGFRB, Pdgfr, Pdgfr1
表達(dá)方式: 
A DNA sequence encoding the rat PDGFRB(Q05030)(Met1-Lys530) was expressed, fused with a polyhistidine tag at the C-terminus.
種屬: Rat
表達(dá)宿主: Human Cells

PDGFRB / PDGFR-1 Protein QC Testing

純度: > 95 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測N端: Leu 32
分子量: 
The recombinant rat PDGFRB comprises 510 amino acids and predicts a molecular mass of 57.6 kDa. The apparent molecular mass of  the recombinant protein is approximately 92 kDa in SDS-PAGE under reducing conditions due to glycosylation.
緩沖液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

PDGFRB / PDGFR-1 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

PDGFRB / PDGFR-1蛋白背景綜述

Beta-type platelet-derived growth factor receptor, also known as CD140b, PDGFRB, PDGF-R-beta, PDGF receptor-β, is a member of the protein kinase superfamily and CSF-1/PDGF receptor subfamily. The PDGF family consists of PDGF-A, -B, -C and -D, which form either homo- or heterodimers (PDGF-AA, -AB, -BB, -CC, -DD). The four PDGFs are inactive in their monomeric forms. The PDGFs bind to the protein tyrosine kinase receptors PDGF receptor-α and -β. These two receptor isoforms dimerize upon binding the PDGF dimer, leading to three possible receptor combinations, namely -αα, -ββ and -αβ. The extracellular region of the PDGF receptor-β consists of five immunoglobulin-like domains while the intracellular part is a tyrosine kinase domain. The ligand-binding sites of PDGF receptor-α and -β are located to the three first immunoglobulin-like domains. PDGF-CC specifically interacts with PDGFR-αα and -αβ, but not with –ββ, and thereby resembles PDGF-AB. PDGF-DD binds to PDGFR-ββ with high affinity, and to PDGFR-αβ to a much lower extent and is regarded as PDGFR-ββ specific. PDGF-AA binds only to PDGFR-αα, while PDGF-BB is the only PDGF that can bind all three receptor combinations with high affinity.

參考文獻(xiàn)

Chi, KD. et al., 1997, Oncogene 15: 1051-7.
Arcaro, A. et al., 2000, Mol. Cell. Biol. 20: 3817-30.
Bergsten, E. et al., 2001, Nat. Cell Biol. 3: 512-16.
Zhang, Z. et al., 2004, Protein Sci. 13: 2819-24.
Morerio, C. et al., 2004, Cancer Res. 64: 2649-51.

規(guī)格：100ug

關(guān) 鍵 詞：Rat PDGFRB / PDGFR-1 Protein,產(chǎn)品詳情,參數(shù)，實驗室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實驗儀器，廠家

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