GGT1蛋白產(chǎn)品信息

別名: GGT1, Ggt
表達(dá)方式: A DNA sequence encoding the rat GGT1 (P07314) (Pro27-Tyr568) was expressed, fused with a polyhistidine tag at the N-terminus.
種屬: Rat
表達(dá)宿主: Human Cells

GGT1 Protein QC Testing

純度: > 70 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測N端: His
分子量: 
The recombinant rat GGT1 comprises 562 amino acids and has a predicted molecular mass of 61.1 kDa. The apparent molecular mass of the protein is approximately 54-57 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

GGT1 Protein Usage Guide

儲(chǔ)存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

GGT1蛋白背景綜述

GGT1 is a member of the gamma-glutamyltransferase protein family, of which many members have not yet been fully characterized and some of which may represent pseudogenes. GGT1 is composed of a heavy chain and a light chain and can be detected in fetal and ***** kidney and liver, ***** pancreas, stomach, intestine, placenta and lung. It is part of the cell antioxidant defense mechanism. GGT1 catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. It also initiates extracellular glutathione breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH level. Defects in GGT1 can cause glutathionuria, also known as gamma-glutamyltranspeptidase deficiency. It is an autosomal recessive disease.

參考文獻(xiàn)

Bulle F. et al., 1987, Hum Genet. 76 (3) :283-6.
Tate SS. et al., 1988, Arch Biochem Biophys. 262 (2): 397-408.
Tate SS. et al., 1988, Biochem Biophys Res Commun. 154 (3): 1167-73.

規(guī)格：50ug

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