CD68 / Macrosialin蛋白產(chǎn)品信息

別名: CD68
表達(dá)方式: 
A DNA sequence encoding the rat CD68 (Q4FZY1)(Met1-Ser295) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
種屬: Rat
表達(dá)宿主: Human Cells

CD68 / Macrosialin Protein QC Testing

純度: > 85% as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測(cè)N端: Asp 21
分子量: 
The recombinant rat CD68/Fc is a disulfide-linked homodimer. The reduced monomer comprises 517 amino acids and has a predicted molecular mass of 56.5 kDa. The apparent molecular mass of the protein is approximately 87-117 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CD68 / Macrosialin Protein Usage Guide

儲(chǔ)存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD68 / Macrosialin蛋白背景綜述

Macrosialin, also known as CD68 and Gp110, is a single-pass type I  membrane protein which belongs to the LAMP family. CD68 is highly expressed by blood monocytes and tissue macrophages. It is also expressed in lymphocytes, fibroblasts and endothelial cells. CD68 is expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. CD68 plays a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It is a commonly used marker for macrophages. However, a number of studies have shown that CD68 antibodies react with other hematopoietic and non-hematopoietic cell types, suggesting that CD68 may not be a macrophage-specific antigen. CD68 binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

參考文獻(xiàn)

Strobl H. et al., 1995, Br J Haematol. 90 (4): 774-82.
Ogawa Y. et al., 1995, Pathol Int. 45 (9): 698-701.
Sadovnikova E. et al., 2002,Leukemia. 16 (10): 2019-26.
Gottfried E. et al., 2008, Scand J Immunol. 67 (5): 453-63.
Strojnik T. et al., 2009, Anticancer Res. 29 (8): 3269-79.

規(guī)格：50ug

關(guān) 鍵 詞：Rat CD68 / Macrosialin Protein,技術(shù)資料,廠家價(jià)格，實(shí)驗(yàn)室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實(shí)驗(yàn)儀器，廠家

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