TNFRSF11A蛋白產(chǎn)品信息

別名: TNFRSF11A
表達(dá)方式: 
A DNA sequence encoding the rat TNFRSF11A(Met1-Pro213) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
種屬: Rat
表達(dá)宿主: Human Cells

TNFRSF11A Protein QC Testing

純度: > 80% as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測(cè)N端: Val 31
分子量: 
The recombinant rat TNFRSF11A/Fc is a disulfide-linked homodimer. The reduced monomer comprises 424 amino acids and has a predicted molecular mass of 47.1 kDa. The apparent molecular mass of the protein is approximately 61 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

TNFRSF11A Protein Usage Guide

儲(chǔ)存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TNFRSF11A蛋白背景綜述

TNFRSF11A, also known as CD265, contains 4 TNFR-Cys repeats and belongs to the TNF-receptor superfamily. TNFRSF11A has an ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. TNFRSF11A can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. TNFRSF11A and its ligand are important regulators of the interaction between T cells and dendritic cells. It is also an essential mediator for osteoclast and lymph node development. Defects in TNFRSF11A are the cause of familial expansile osteolysis (FEO). FEO is a rare autosomal dominant bone disorder characterized by focal areas of increased bone remodeling. Defects in TNFRSF11A also can cause Paget disease of bone type 2 (PDB2). PDB2 is a bone-remodeling disorder with clinical similarities to FEO. Defects in TNFRSF11A are the cause of osteopetrosis autosomal recessive type 7 which characterized by abnormally dense bone, due to defective resorption of immature bone.

參考文獻(xiàn)

Darnay B G. et al., 1998, J Biol Chem. 273 (32): 20551-5.
Darnay B G. et al., 1999, J Biol Chem. 274 (12): 7724-31.
Galibert L. et al., 1998, J Biol Chem. 273 (51): 34120-7.

規(guī)格：100ug

關(guān) 鍵 詞：Rat TNFRSF11A Protein，產(chǎn)品詳情，參數(shù)，實(shí)驗(yàn)室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實(shí)驗(yàn)儀器，廠家

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