KLK7 / Kallikrein 7蛋白產(chǎn)品信息

別名: KLK7, Prss6, Scce
表達(dá)方式: 
A DNA sequence encoding the mouse KLK7 (Q91VE3) (Met1-Arg249) was expressed with a C-terminal polyhistidine tag.
種屬: Mouse
表達(dá)宿主: Human Cells

KLK7 / Kallikrein 7 Protein QC Testing

純度: >(71.4+26)% as determined by SDS-PAGE SDS-PAGE:

KLK7 / Kallikrein 7 protein
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測(cè)N端: Gln 22
分子量: 
The recombinant mouse KLK7 comprises 239 amino acids and has a predicted molecular mass of 26.5 kDa. The apparent molecular mass of the protein is approximately 31 and 34 kDa in SDS-PAGE under reducing conditions due to glycosylation.
緩沖液: Lyophilized from sterile PBS, pH7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

KLK7 / Kallikrein 7 Protein Usage Guide

儲(chǔ)存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
 
KLK7 / Kallikrein 7蛋白背景綜述

Kallikrein-7, also known as kallikrein-related peptidase 7, Stratum corneum chymotryptic enzyme, Serine protease 6, KLK7, and PRSS6, is a secreted protein which belongs to the peptidase S1 family and Kallikrein subfamily. Members of the Kallikrein family are involved in various malignancies such as prostate (PSA, KLK2, KLK15), ovarian (KLK4, KLK5, KLK6, KLK8, KLK10), and breast cancer (KLK10, KLK13, KLK14). Kallikrein-7 / KLK7 appears to be increased in ovarian cancer and higher KLK7 expression in ovarian cancer tissue is associated with poorer prognosis of ovarian cancer patients. Kallikrein-7 / KLK7 is abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Kallikrein-7 / KLK7 is up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at the protein level). It was significantly associated with shorter overall survival (OS) and disease-free survival (DFS). Kallikrein-7 / KLK7 may catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. KLK7 also plays a role in the activation of precursors to inflammatory cytokines.

參考文獻(xiàn)

Dong Y. et al., 2003, Clin Cancer Res. 9 (5): 1710-20.
Kyriakopoulou LG. et al., 2003, Clin Biochem. 36 (2): 135-43.
Talieri M. et al.,2004,Thromb Haemost. 91 (1): 180-6.
Talieri M. et al., 2009, Thromb Haemost. 101 (4): 741-7.

規(guī)格：10ug

關(guān) 鍵 詞：Mouse KLK7 / Kallikrein 7 Protein,技術(shù)資料,參數(shù)，實(shí)驗(yàn)室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實(shí)驗(yàn)儀器，廠家

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