EPCAM蛋白產(chǎn)品信息

別名: EPCAM, Tacstd1
表達(dá)方式: 
A DNA sequence encoding the rat EPCAM(O55159)(Met1-Thr266) was expressed, fused with a polyhistidine tag at the C-terminus.
種屬: Rat
表達(dá)宿主: Human Cells

EPCAM Protein QC Testing

純度: > 97 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測N端: Gln 24
分子量: 
The recombinant rat EPCAM comprises 254 amino acids and predicts a molecular mass of 29.2 kDa. The apparent molecular mass of  the recombinant protein is approximately 39 kDa in SDS-PAGE under reducing conditions due to glycosylation.
緩沖液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

EPCAM Protein Usage Guide

儲(chǔ)存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

EPCAM蛋白背景綜述

Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type I transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. This protein is present in the majority of human epithelial cells and is highly expressed in gastrointestinal carcinomas. It has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. Since the cell-cell adhesion is known to play an important role in tumor progression and metastasis, the high expression of GA733-2 antigen is associated with malignant tumor development in various types of cancer lesions. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. EpCAM is being used as a target for immunotherapy treatment of human carcinomas.

參考文獻(xiàn)

Simon B. et al., 1990, Proc Natl Acad Sci. 87: 2755-9.
Chong JM. et al., 2001, J. Biol. Chem. 276: 5804 - 13.
Litvinov SV. et al., 1994, J Cell Biol. 125: 437-46.
Balzar M. et al., 1999. J Mol Med. 77: 699-712.
Yamashita T. et al., 2007, Cancer Res. 67: 10831-9.

規(guī)格：50ug

關(guān) 鍵 詞：Rat EPCAM Protein,鼠EPCAM蛋白質(zhì),產(chǎn)品詳情，實(shí)驗(yàn)室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實(shí)驗(yàn)儀器，廠家

CANSPEC品質(zhì)提供的Rat EPCAM Protein|鼠EPCAM蛋白質(zhì)|廠家|產(chǎn)品詳情性能**，其優(yōu)良的品質(zhì)滿足您不同實(shí)驗(yàn)的多種需求。

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