C7 / Complement component 7蛋白產(chǎn)品信息

別名: C7
表達方式: 
A DNA sequence encoding the human C7 (P10643)(Met1-Gln843 )with a C-terminal polyhistidine tag was expressed.
種屬: Human
表達宿主: Human Cells

C7 / Complement component 7 Protein QC Testing

純度: > 88 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測N端: Ser 23
分子量: The recombinant human C7  comprises 832 amino acids and has a predicted molecular mass of 92.6 kDa. The apparent molecular mass of the protein is approximately 92-98 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile  PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

C7 / Complement component 7 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

C7 / Complement component 7蛋白背景綜述

Complement component 7 is a member of the complement C6/C7/C8/C9 family. It contains 1 EGF-like domain, 1 LDL-receptor class A domain, 1 MACPF domain, 2 Sushi (CCP/SCR) domains and 2 TSP type-1 domains. As a component of the complement system. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. As a constituent of MAC, it plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Complement component 7 serves as a membrane anchor. Defects in C7 are a cause of complement component 7 deficiency (C7D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.

參考文獻

Bossi F. t al., 2009, Blood. 113 (15): 3640-8.
Kuijpers TW. et al., 2010, Mol Immunol. 47 (4): 671-7.
Thomas AD. et al., 2012, Mol Immunol. 50 (1-2): 57-9.

規(guī)格：50ug

關(guān) 鍵 詞：C7 / Complement component 7 Protein,技術(shù)資料,價格，實驗室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實驗儀器，廠家

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