NRG1蛋白產(chǎn)品信息

別名: NRG1, GGF, HGL, HRGA, NDF, SMDF
表達方式: A DNA sequence encoding the human NRG1(Q02297--isoform6) (Ser2-Lys246) was expressed, fused with the Fc region of mouse IgG1 at the N-terminus.
種屬: Human
表達宿主: Human Cells

NRG1 Protein QC Testing

純度: > 88 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測N端: Asp
分子量: 
The recombinant human NRG1/mFc comprises 481 amino acids and has a predicted molecular mass of 53.4 kDa. The apparent molecular mass of the monomer is approximately 67 kDa in SDS-PAGE under reducing conditions due to glycosylation.
緩沖液: Lyophilized from sterile PBS,pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

NRG1 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

NRG1蛋白背景綜述

Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.

參考文獻

Nicodemus KK. et al., 2010, Arch Gen Psychiatry. 67 (10): 991-1001.
Tan W. et al., 2007, J Biol Chem. 282 (33): 24343-51.
Holmes WE. et al., 1992, Science. 256 (5060): 1205-10.

規(guī)格：50ug

關(guān) 鍵 詞：NRG1 (aa 2-246) Protein,NRG1(aa 2 - 246)蛋白,技術(shù)資料,產(chǎn)品詳情，實驗室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實驗儀器，廠家

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