GPX7 蛋白產(chǎn)品信息

別名: GPX7, GPX6
表達(dá)方式: A DNA sequence encoding the human GPX7(NP_056511.2) (Met1-Leu187) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
種屬:  Human
表達(dá)宿主: Human Cells

GPX7 Protein QC Testing

純度: >95 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測N端: Gln 20
分子量: The recombinant human GPX7/Fc is a disulfide-linked homodimer. The reduced monomer comprises 408 amino acids and has a predicted molecular mass of 46.1 kDa. The apparent molecular mass of the protein is approximately kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

GPX7 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

GPX7 蛋白背景綜述

GPX7 is an enzyme. GPX7 gene contains 3 distinct gt-ag introns. Transcription produces 4 different mRNAs, 3 alternatively spliced variants and 1 unspliced form. There are 5 validated alternative polyadenylation sites. The mRNAs appear to differ by overlapping exons with different boundaries. Functionally, the gene has been proposed to participate in pathways (Arachidonic acid metabolism, Glutathione metabolism) and processes (oxidation reduction, response to oxidative stress). GPX7 has molecular functions (glutathione peroxidase activity, oxidoreductase activity) and to localize in various compartments (extracellular space, extracellular region). GPX7 modulates the bone turnover after ovariectomy in rats, it does not compensate for the action of estrogen after ovariectomy in rats. It has been shown that three mAbs (GPX7, GPX22 and GPZ35) inhibit IL-6-mediated biological responses such as Ig production in a human B cell line and proliferative responses of a human Lennert's lymphoma-derived T cell line, a human myeloma cell line, and a mouse pro-B cell line-derived transfectant expressing human gp130.

參考文獻(xiàn)

Rual JF. et al., 2005, Nature. 437 (7062): 1173-8.
Gregory SG. et al., 2006, Nature. 441 (7091): 315-21.
Lim J. et al., 2006, Cell. 125 (4): 801-14.

規(guī)格：50ug

關(guān) 鍵 詞：GPX7 / Glutathione Peroxidase 7 Protein,品詳情,數(shù)，實(shí)驗(yàn)室耗材，生化試劑，上海創(chuàng)賽，博飛美科，實(shí)驗(yàn)儀器，廠家

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