Fn14 / TNFRSF12A蛋白產(chǎn)品信息
產(chǎn)品名稱：重組人 Fn14 / TNFRSF12A 蛋白|Fn14 / TNFRSF12A Protein|生產(chǎn)廠家|價格
別名: CD266, FN14, TWEAKR
表達(dá)方式: 
A DNA sequence encoding the human TNFRSF12A isoform 1 (Q9NP84-1) extracellular domain (Glu 28-Trp 79) was fused with the Fc region of human IgG1 at the N-terminus.
種屬: Human
表達(dá)宿主: Human Cells

Fn14 / TNFRSF12A蛋白質(zhì)控指標(biāo)
純度: > 95 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測N端: Glu
分子量: The recombinant human TNFRSF12A/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 313 amino acids and has a calculated molecular mass of 34 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhTNFRSF12A/Fc monomer is approximately 37 kDa.
緩沖液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

Fn14 / TNFRSF12A蛋白使用指南
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Fn14 / TNFRSF12A蛋白背景綜述
Fn14 (tumor necrosis factor receptor superfamily, member 12A), also known as TNFRSF12A, is the receptor for TNFSF12/TWEAK. TNFRSF12 is the tiniest member of the TNF receptor superfamily and has only one cysteine rich region in its extracellular domain. The TNFRSF12A cytoplasmic domain holds one TRAF binding motif which binds TRAFs 1, 2, and 3. TNFRSF12A binds its ligand TWEAK/TNFSF12A with high affinity to initiate a signal transduction cascade which subject to the cell type, causes different cellular responses such as cell death, cell proliferation, and angiogenesis. The gene for TNFRSF12A was initially recognized as a fibroblast growth factor inducible immediate early response gene Fn14 in mouse NIH 3T3 fibroblasts. Fn14 can be detected in heart, placenta, kidney, lung, skeletal muscle, pancreas, brain and liver. It is the weak inducer of apoptosis in some cell types. Fn14 promotes angiogenesis and the proliferation of endothelial cells. It may modulate cellular adhesion to matrix proteins.
參考文獻(xiàn)
Burkly LC. et al., 2011, Adv Exp Med Biol. 691:305-22.
Huang M. et al., 2011, Carcinogenesis. 32(11):1589-96.
Dharmapatni AA. et al., 2011, Arthritis Res Ther. 13(2):R51.

包裝：50ug

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